Lupus patients with peripheral vascular thrombosis: The significance of measuring anticardiolipin antibody

Chrong Reen Wang, Chen Cheng Chou, Kue Hsiung Hsieh, Che Yen Chuang, Chen Yen Chen

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The purpose of this study was to determine the significance of measuring anticardiolipin (ACL) antibodies in Chinese lupus patients with peripheral vascular thrombosis. A total of 252 lupus patients were evaluated prospectively for the presence of peripheral vascular thrombosis in a 3-year period. Tests of ACL antibodies with three isotypes were done serially during follow-up. There were 10 lupus patients with five episodes of arterial thrombosis and seven episodes of venous thrombosis by the evidences of angiographical and/or pathological findings. The ACL antibody status was negative (<2 standard deviation [SD]), low (2 to 5 SD) and high (>5 SD) for 43.3%, 22.6%, and 34.1% patients, respectively. Patients with high levels (>5 SD) of ACL antibodies had a high frequency of peripheral vascular thrombosis than patients with negative levels (>2 SD) of ACL antibodies (P < .05). It is concluded that serial measurement of ACL antibodies in lupus patients is useful in predicting the occurrence of peripheral vascular thrombosis. Cliniclans should be alert to the possibility of such complication in lupus patients with high ACL antibodies levels when visiting the emergency service.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalAmerican Journal of Emergency Medicine
Volume11
Issue number5
DOIs
Publication statusPublished - 1993 Sep

All Science Journal Classification (ASJC) codes

  • Emergency Medicine

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