Macromolecular ion accelerator

Yun Fei Hsu; Jung Lee Lin; Szu Hsueh Lai; Ming Lee Chu; Yi Sheng Wang; Chung Hsuan Chen

doi:10.1021/ac301022n

Macromolecular ion accelerator

Yun Fei Hsu
, Jung Lee Lin
, Szu Hsueh Lai
, Ming Lee Chu
, Yi Sheng Wang
, Chung Hsuan Chen

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Presented herein are the development of macromolecular ion accelerator (MIA) and the results obtained by MIA. This new instrument utilizes a consecutive series of planar electrodes for the purpose of facilitating stepwise acceleration. Matrix-assisted laser desorption/ionization (MALDI) is employed to generate singly charged macromolecular ions. A regular Z-gap microchannel plate (MCP) detector is mounted at the end of the accelerator to record the ion signals. In this work, we demonstrated the detection of ions with the mass-to-charge (m/z) ratio reaching 30-000-000. Moreover, we showed that singly charged biomolecular ions can be accelerated with the voltage approaching 1 MV, offering the evidence that macromolecular ions can possess much higher kinetic energy than ever before.

Original language	English
Pages (from-to)	5765-5769
Number of pages	5
Journal	Analytical Chemistry
Volume	84
Issue number	13
DOIs	https://doi.org/10.1021/ac301022n
Publication status	Published - 2012 Jul 3

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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10.1021/ac301022n

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abstract = "Presented herein are the development of macromolecular ion accelerator (MIA) and the results obtained by MIA. This new instrument utilizes a consecutive series of planar electrodes for the purpose of facilitating stepwise acceleration. Matrix-assisted laser desorption/ionization (MALDI) is employed to generate singly charged macromolecular ions. A regular Z-gap microchannel plate (MCP) detector is mounted at the end of the accelerator to record the ion signals. In this work, we demonstrated the detection of ions with the mass-to-charge (m/z) ratio reaching 30-000-000. Moreover, we showed that singly charged biomolecular ions can be accelerated with the voltage approaching 1 MV, offering the evidence that macromolecular ions can possess much higher kinetic energy than ever before.",

author = "Hsu, \{Yun Fei\} and Lin, \{Jung Lee\} and Lai, \{Szu Hsueh\} and Chu, \{Ming Lee\} and Wang, \{Yi Sheng\} and Chen, \{Chung Hsuan\}",

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doi = "10.1021/ac301022n",

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T1 - Macromolecular ion accelerator

AU - Hsu, Yun Fei

AU - Lin, Jung Lee

AU - Lai, Szu Hsueh

AU - Chu, Ming Lee

AU - Wang, Yi Sheng

AU - Chen, Chung Hsuan

PY - 2012/7/3

Y1 - 2012/7/3

N2 - Presented herein are the development of macromolecular ion accelerator (MIA) and the results obtained by MIA. This new instrument utilizes a consecutive series of planar electrodes for the purpose of facilitating stepwise acceleration. Matrix-assisted laser desorption/ionization (MALDI) is employed to generate singly charged macromolecular ions. A regular Z-gap microchannel plate (MCP) detector is mounted at the end of the accelerator to record the ion signals. In this work, we demonstrated the detection of ions with the mass-to-charge (m/z) ratio reaching 30-000-000. Moreover, we showed that singly charged biomolecular ions can be accelerated with the voltage approaching 1 MV, offering the evidence that macromolecular ions can possess much higher kinetic energy than ever before.

AB - Presented herein are the development of macromolecular ion accelerator (MIA) and the results obtained by MIA. This new instrument utilizes a consecutive series of planar electrodes for the purpose of facilitating stepwise acceleration. Matrix-assisted laser desorption/ionization (MALDI) is employed to generate singly charged macromolecular ions. A regular Z-gap microchannel plate (MCP) detector is mounted at the end of the accelerator to record the ion signals. In this work, we demonstrated the detection of ions with the mass-to-charge (m/z) ratio reaching 30-000-000. Moreover, we showed that singly charged biomolecular ions can be accelerated with the voltage approaching 1 MV, offering the evidence that macromolecular ions can possess much higher kinetic energy than ever before.

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U2 - 10.1021/ac301022n

DO - 10.1021/ac301022n

M3 - Article

AN - SCOPUS:84863442678

SN - 0003-2700

VL - 84

SP - 5765

EP - 5769

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 13

ER -

Macromolecular ion accelerator

Abstract

All Science Journal Classification (ASJC) codes

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