Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas

Ting Ying Fu, Yu Yi Hou, Sau Tung Chu, Ching Feng Liu, Cheng Hui Huang, Hung Chih Chen, Michael Hsiao, Pei-Jung Lu, Jyh Seng Wang, Luo Ping Ger

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis. Methods The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry in a series of 216 surgically resected buccal mucosal SCC specimens, using tissue microarray slides. Results MnSOD, GPx, catalase, and MPO were commonly expressed in buccal mucosal SCC. The high expression level of MnSOD was associated with better disease-specific survival (p =.009), especially for patients in moderate or poor cell differentiation (p =.045), pathologic stage I (p =.002) and postoperative radiotherapy (p =.048). The high expression level of GPx was also correlated with better disease-specific survival (p =.042), especially for patients in pathologic stage IV (p =.010) and postoperative radiotherapy (p =.018). Conclusions MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC.

Original languageEnglish
Pages (from-to)1606-1615
Number of pages10
JournalHead and Neck
Volume33
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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