The manganese(III) initiated oxidative free radical reaction between 1,4-naphthoquinones and ethyl nitroacetate is described. Nitromethyl radical 1 can be generated effectively from the oxidation of ethyl nitroacetate by manganese(III) acetate. Naphtho[2,3-d]isoxazole-4,9-diones, benzo[f]indole- 4,9-diones and benzo[b]acridine-6,11-diones were prepared effectively from readily available 1,4-naphthoquinones and ethyl nitroacetate.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry