Manipulating Cellular Activities Using an Ultrasound-Chemical Hybrid Tool

Ching Hsiang Fan, Yao Shen Huang, Wei En Huang, Albert Alexander Lee, Sheng Yang Ho, Yu Lin Kao, Cuei Ling Wang, Yen Ling Lian, Tasuku Ueno, Tsung Shing Andrew Wang, Chih Kuang Yeh, Yu Chun Lin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We developed an ultrasound-chemical hybrid tool to precisely manipulate cellular activities. A focused ultrasound coupled with gas-filled microbubbles was used to rapidly trigger the influx of membrane-impermeable chemical dimerizers into living cells to regulate protein dimerization and location without inducing noticeable toxicity. With this system, we demonstrated the successful modulation of phospholipid metabolism triggered by a short pulse of ultrasound exposure. Our technique offers a powerful and versatile tool for using ultrasound to spatiotemporally manipulate the cellular physiology in living cells.

Original languageEnglish
Pages (from-to)2021-2027
Number of pages7
JournalACS Synthetic Biology
Issue number11
Publication statusPublished - 2017 Nov 17

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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