TY - JOUR
T1 - Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–A review
AU - Chen, Bailing
AU - Wan, Chun
AU - Mehmood, Muhammad Aamer
AU - Chang, Jo Shu
AU - Bai, Fengwu
AU - Zhao, Xinqing
N1 - Funding Information:
This work was financially supported by the National Natural Science Foundation of China with the grant reference number of No. 21536006 .
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017
Y1 - 2017
N2 - Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.
AB - Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.
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U2 - 10.1016/j.biortech.2017.05.170
DO - 10.1016/j.biortech.2017.05.170
M3 - Review article
C2 - 28601395
AN - SCOPUS:85020380703
SN - 0960-8524
VL - 244
SP - 1198
EP - 1206
JO - Bioresource technology
JF - Bioresource technology
ER -