Manipulating environmental stresses and stress tolerance of microalgae for enhanced production of lipids and value-added products–A review

Bailing Chen, Chun Wan, Muhammad Aamer Mehmood, Jo-Shu Chang, Fengwu Bai, Xinqing Zhao

Research output: Contribution to journalReview article

65 Citations (Scopus)


Microalgae have promising potential to produce lipids and a variety of high-value chemicals. Suitable stress conditions such as nitrogen starvation and high salinity could stimulate synthesis and accumulation of lipids and high-value products by microalgae, therefore, various stress-modification strategies were developed to manipulate and optimize cultivation processes to enhance bioproduction efficiency. On the other hand, advancements in omics-based technologies have boosted the research to globally understand microalgal gene regulation under stress conditions, which enable further improvement of production efficiency via genetic engineering. Moreover, integration of multi-omics data, synthetic biology design, and genetic engineering manipulations exhibits a tremendous potential in the betterment of microalgal biorefinery. This review discusses the process manipulation strategies and omics studies on understanding the regulation of metabolite biosynthesis under various stressful conditions, and proposes genetic engineering of microalgae to improve bioproduction via manipulating stress tolerance.

Original languageEnglish
Pages (from-to)1198-1206
Number of pages9
JournalBioresource technology
Publication statusPublished - 2017 Jan 1


All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

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