Manipulating T-junction chip for the generation of uniform O/W and W/O emulsions

Chia Hsien Yeh, Sheng Ji Lee, Meng Sun, Qun Fang, Yu-Cheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The purpose of this study is to generate monodisperse oil-in-water (O/W) and water-in-oil (W/O) emulsions using microfluidic T-junction. The materials of poly methyl methacrylate (PMMA) (hydrophobic), polydimethylsiloxane (PDMS) (hydrophobic) and glass (hydrophilic) were employed for microfluidic chip fabrication. Our strategy is based on the shear focus effect and sheath effect (focusing) to form uniform self-assembling sphere structures, the so-called O/W and W/O emulsions, in the T-junction microchannel. Results show that the size from 31 μm to 43 μm in diameter of O/W emulsions was generated by using the glass-based microfluidic chip. In addition, results show that the size from 70 μm to 220 μm of W/O emulsions was available by utilizing the PMMA-based microfluidic chip. These W/O emulsions were further applied to Ca-alginate microparticles (Ca-alg MPs). And the results also show that the size from 410 μm to 700 μm of UV-Photopolymerized microparticles was available by utilizing the PDMS-based microfluidic chip. The proposed microfluidic chips are capable of generating relatively uniform micro-droplets and have the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput.

Original languageEnglish
Title of host publicationMicrofluidics, BioMEMS, and Medical Microsystems VI
DOIs
Publication statusPublished - 2008 Mar 31
EventMicrofluidics, BioMEMS, and Medical Microsystems VI - San Jose, CA, United States
Duration: 2008 Jan 212008 Jan 22

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6886
ISSN (Print)0277-786X

Other

OtherMicrofluidics, BioMEMS, and Medical Microsystems VI
CountryUnited States
CitySan Jose, CA
Period08-01-2108-01-22

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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