Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles

Keng Shiang Huang, Tzung Heng Lai, Yu Cheng Lin

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

In this paper the manipulation of Ca-alginate microspheres, using a microfluidic chip, for the encapsulation of gold nanoparticles is presented. Our strategy is based on hydrodynamic-focusing on the forming of a series of self-assembling sphere structures, the so-called water-in-oil (w/o) emulsions, in the cross-junction microchannel. These fine emulsions, consisting of aqueous Na-alginates, are then dripped into a solution of 20% calcium salt to accomplish Ca-alginate microspheres in an efficient manner. Experimental data show that microspheres with diameters ranging from 50 μm to 2000 μm with a variation less than 5% were precisely generated. The size and gap of the droplets are tunable by adjusting the relative sheath/sample flow rate ratio. Furthermore, we applied them to encapsulated gold nanoparticles, and this one shot operation performs the 'Lab on a Chip'.

Original languageEnglish
Pages (from-to)954-957
Number of pages4
JournalLab on a Chip
Volume6
Issue number7
DOIs
Publication statusPublished - 2006 Jan 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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