Abstract
This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.
| Original language | English |
|---|---|
| Pages | 1115-1117 |
| Number of pages | 3 |
| Publication status | Published - 2006 Jan 1 |
| Event | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 2006 Nov 5 → 2006 Nov 9 |
Other
| Other | 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 |
|---|---|
| Country | Japan |
| City | Tokyo |
| Period | 06-11-05 → 06-11-09 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Bioengineering
Cite this
}
Manufacturing size-controlled gelatin microparticles using a microfluidic chip. / Lin, Yu-Cheng; Huang, Keng Shiang; Lai, Shian Chin; Lai, Yu Jen; Lin, Po Wen; Yang, Chih Hui.
2006. 1115-1117 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.Research output: Contribution to conference › Paper
TY - CONF
T1 - Manufacturing size-controlled gelatin microparticles using a microfluidic chip
AU - Lin, Yu-Cheng
AU - Huang, Keng Shiang
AU - Lai, Shian Chin
AU - Lai, Yu Jen
AU - Lin, Po Wen
AU - Yang, Chih Hui
PY - 2006/1/1
Y1 - 2006/1/1
N2 - This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.
AB - This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.
UR - http://www.scopus.com/inward/record.url?scp=52249119606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52249119606&partnerID=8YFLogxK
M3 - Paper
AN - SCOPUS:52249119606
SP - 1115
EP - 1117
ER -