Manufacturing size-controlled gelatin microparticles using a microfluidic chip

Yu-Cheng Lin, Keng Shiang Huang, Shian Chin Lai, Yu Jen Lai, Po Wen Lin, Chih Hui Yang

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.

Original languageEnglish
Pages1115-1117
Number of pages3
Publication statusPublished - 2006 Jan 1
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: 2006 Nov 52006 Nov 9

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period06-11-0506-11-09

Fingerprint

Gelatin
Microfluidics
Chitosan
Emulsions
Microspheres
Oils
Flow rate
Throughput
Pharmaceutical Preparations
Costs

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Lin, Y-C., Huang, K. S., Lai, S. C., Lai, Y. J., Lin, P. W., & Yang, C. H. (2006). Manufacturing size-controlled gelatin microparticles using a microfluidic chip. 1115-1117. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.
Lin, Yu-Cheng ; Huang, Keng Shiang ; Lai, Shian Chin ; Lai, Yu Jen ; Lin, Po Wen ; Yang, Chih Hui. / Manufacturing size-controlled gelatin microparticles using a microfluidic chip. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.3 p.
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Lin, Y-C, Huang, KS, Lai, SC, Lai, YJ, Lin, PW & Yang, CH 2006, 'Manufacturing size-controlled gelatin microparticles using a microfluidic chip' Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan, 06-11-05 - 06-11-09, pp. 1115-1117.

Manufacturing size-controlled gelatin microparticles using a microfluidic chip. / Lin, Yu-Cheng; Huang, Keng Shiang; Lai, Shian Chin; Lai, Yu Jen; Lin, Po Wen; Yang, Chih Hui.

2006. 1115-1117 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Contribution to conferencePaper

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N2 - This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.

AB - This study is to prepare monodisperse gelatin microparticles using a microfluidic chip. We have demonstrated that one can control the size of gelatin microparticles from 100 μm to 400 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets and has the advantages of actively controlling the droplet diameter, and having a simple and low cost process, with a high throughput. Experimental data show that when given a steady continuous phase (oil flow), the emulsion size increases with the increase in average velocity of the dispersed phase flow (sample flow). In addition, the size distribution of the resulting chitosan microspheres is narrow (about Polyindex = 1) which is suitable to provide the optimal release rate in the administration of controlled release drugs.

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Lin Y-C, Huang KS, Lai SC, Lai YJ, Lin PW, Yang CH. Manufacturing size-controlled gelatin microparticles using a microfluidic chip. 2006. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.