Abstract
LAT (latency-associated transcript) is the only herpes simplex virus type 1 (HSV-1) transcript abundantly expressed during neuronal latency. LAT expression is required for the high reactivation phenotype of HSV-1 and this phenotype correlates with LAT's anti-apoptosis properties. LAT nucleotides 1 to 1499 inhibit caspase-8 (death receptor apoptotic pathway), but not caspase-9 (mitochondrial apoptotic pathway), -induced apoptosis as efficiently as larger LAT fragments. LAT sequences important for inhibiting caspase-8-induced apoptosis were also localized. The ability of LAT nucleotides 1 to 1499 to efficiently inhibit caspase-8-induced apoptosis correlates with the high reactivation phenotype of a mutant virus expressing just the first 1.5 kb of LAT (nucleotides 1 to 1499).
Original language | English |
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Pages (from-to) | 260-265 |
Number of pages | 6 |
Journal | Journal of NeuroVirology |
Volume | 10 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2004 Aug |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology