Maternal derivative chromosome 9 and recurrent pregnancy loss

Objective: To disclose the relationship between a derivative chromosome 9 and recurrent pregnancy loss. Design: Case report. Setting: Referral from primary clinical care to tertiary hospital for further intervention. Patient(s): A 31-year-old woman who had four recurrent early spontaneous abortions. Intervention(s): Cytogenetic and fluorescence in situ hybridization analyses of the chromosome harvested from peripheral blood sample. Main Outcome Measure(s): Karyotype of the patient. Result(s): The patient has a unique derivative chromosome 9, der(9)(9qter→9p24::9p24→9p11::9p13→9qter). ish der(9) (CEP9×1,43N6×1,D9Z3×1). Conclusion(s): Maternal derivative chromosome 9 may cause recurrent pregnancy loss.