Maternal diabetes programs hypertension and kidney injury in offspring

Yun-Wen Chen, Isabelle Chenier, Stella Tran, Michael Scotcher, Shiao Ying Chang, Shao Ling Zhang

Research output: Contribution to journalArticle

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Abstract

We investigated whether maternal diabetes programs the offspring to develop hypertension and kidney injury in adulthood and examined potential underlying mechanisms. In a murine model we studied the offspring of three groups of dams (non-diabetic, diabetic, and diabetic treated with insulin). Mean systolic blood pressure in the offspring was monitored from 8 to 20 weeks. Body and kidney weights in the offspring of diabetic mothers were significantly lower than in offspring of non-diabetic mothers. Offspring of diabetic mothers developed hypertension, microalbuminuria, and glucose intolerance. Increased accumulation of extracellular matrix proteins in the glomeruli and marked upregulation of angiotensinogen, angiotensin II type 1 receptor, angiotensinconverting enzyme, transforming growth factor beta-1 (TGF-ß1), and plasminogen activator inhibitor-1 (PAI-1) gene expression were evident in the renal cortex of hypertensive offspring of diabetic mothers. By contrast, angiotensinconverting enzyme-2 (ACE2) gene expression was lower in the hypertensive offspring of diabetic mothers than in that of non-diabetic mothers. These changes were prevented in the offspring of insulin-treated diabetic mothers. These data indicate that maternal diabetes induces perinatal programming of hypertension, renal injury, and glucose intolerance in the offspring and suggest a central role for the activation of the intrarenal renin-angiotensin system and TGF-ß1 gene expression in this process.

Original languageEnglish
Pages (from-to)1319-1329
Number of pages11
JournalPediatric Nephrology
Volume25
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

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Glucose Intolerance
Mothers
Hypertension
Kidney
Gene Expression
Transforming Growth Factor beta
Wounds and Injuries
Insulin
Blood Pressure
Angiotensinogen
Angiotensin Type 1 Receptor
Renal Hypertension
Extracellular Matrix Proteins
Plasminogen Activator Inhibitor 1
Enzymes
Renin-Angiotensin System
Up-Regulation
Body Weight

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Chen, Y-W., Chenier, I., Tran, S., Scotcher, M., Chang, S. Y., & Zhang, S. L. (2010). Maternal diabetes programs hypertension and kidney injury in offspring. Pediatric Nephrology, 25(7), 1319-1329. https://doi.org/10.1007/s00467-010-1506-1
Chen, Yun-Wen ; Chenier, Isabelle ; Tran, Stella ; Scotcher, Michael ; Chang, Shiao Ying ; Zhang, Shao Ling. / Maternal diabetes programs hypertension and kidney injury in offspring. In: Pediatric Nephrology. 2010 ; Vol. 25, No. 7. pp. 1319-1329.
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Chen, Y-W, Chenier, I, Tran, S, Scotcher, M, Chang, SY & Zhang, SL 2010, 'Maternal diabetes programs hypertension and kidney injury in offspring', Pediatric Nephrology, vol. 25, no. 7, pp. 1319-1329. https://doi.org/10.1007/s00467-010-1506-1

Maternal diabetes programs hypertension and kidney injury in offspring. / Chen, Yun-Wen; Chenier, Isabelle; Tran, Stella; Scotcher, Michael; Chang, Shiao Ying; Zhang, Shao Ling.

In: Pediatric Nephrology, Vol. 25, No. 7, 01.07.2010, p. 1319-1329.

Research output: Contribution to journalArticle

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