Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice

Seth R. Ogden, Jennifer M. Noto, Shannon S. Allen, Dilan A. Patel, Judith Romero-Gallo, M. Kay Washington, Barbara Fingleton, Dawn A. Israel, Nuruddeen D. Lewis, Keith T. Wilson, Rupesh Chaturvedi, Zhiguo Zhao, Yu Shyr, Richard M. Peek

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epithelial cells in vitro. Utilizing a transgenic murine model of H. pylori-mediated injury, our experiments now show that gastric inflammation is increased within the context of MMP-7 deficiency, which involves both Th1- and Th17-mediated pathways. Enhanced gastritis in H. pylori-infected mmp-7 -/- mice is strongly linked to accelerated epithelial cellular turnover. However, more severe inflammation and heightened proliferation and apoptosis are not dependent on MMP-7-mediated bacterial eradication. Collectively, these studies indicate that H. pylori-mediated induction of MMP-7 may serve to protect the gastric mucosa from pathophysiologic processes that promote carcinogenesis.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalCancer Research
Volume70
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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