TY - JOUR
T1 - Measurement of optic nerve sheath diameter by ultrasound in healthy term neonates
AU - Lan, Shih Yun
AU - Tai, Hung Lin
AU - Lin, Jainn Jim
AU - Lan, Fan Yun
AU - Tsai, Hsin Yu
AU - Lin, Kuang Lin
N1 - Funding Information:
The authors would like to thank the support of the Study Group of Intensive and Integrated Care for Pediatric Central Nervous System (iCNS Group) at Chang Gung Children's Hospital in Taoyuan, Taiwan.
Publisher Copyright:
© 2021
PY - 2021/11
Y1 - 2021/11
N2 - Background: Optic nerve sheath diameter (ONSD) ultrasound is a noninvasive and repeatable tool to dynamically evaluate intracranial pressure with high diagnostic accuracy; however, data in neonates are scarce. The aim of this study was to determine the reference value of ONSD and potential influencing factors in healthy term neonates. Methods: We retrospectively reviewed 250 full-term neonates who underwent cranial ultrasound as part of selective newborn screening over a 2-year period. Neonates with any of the following conditions were excluded: using mechanical ventilation, sedatives and/or vasopressors, or signs of infection which needed cerebrospinal fluid analysis and/or intracranial pathologies. Data on sex, gestational age, birth body weight, birth body height, birth head circumference, Apgar score and types of delivery were collected. The neurodevelopmental outcomes were reviewed. Results: A total of 234 neonates (123 girls and 111 boys) were included. The mean ONSD value was 3.30 ± 0.27 mm in the right eye and 3.30 ± 0.23 mm in the left eye, with no significant difference between both eyes (p = 0.797). Male neonates had a larger ONSD than female neonates (3.34 ± 0.22 mm versus 3.26 ± 0.20 mm, p = 0.007), and ONSD was correlated with birth weight in the males. Otherwise, there were no statistically significant associations between ONSD and other birth characteristics in both sexes. Most (63%) cases were followed for at least 12 months, and 98% had normal neurodevelopment. Conclusion: The reference value reported in this study may be used to evaluate the ONSD in healthy term neonates. Sex differences should be considered in this age group.
AB - Background: Optic nerve sheath diameter (ONSD) ultrasound is a noninvasive and repeatable tool to dynamically evaluate intracranial pressure with high diagnostic accuracy; however, data in neonates are scarce. The aim of this study was to determine the reference value of ONSD and potential influencing factors in healthy term neonates. Methods: We retrospectively reviewed 250 full-term neonates who underwent cranial ultrasound as part of selective newborn screening over a 2-year period. Neonates with any of the following conditions were excluded: using mechanical ventilation, sedatives and/or vasopressors, or signs of infection which needed cerebrospinal fluid analysis and/or intracranial pathologies. Data on sex, gestational age, birth body weight, birth body height, birth head circumference, Apgar score and types of delivery were collected. The neurodevelopmental outcomes were reviewed. Results: A total of 234 neonates (123 girls and 111 boys) were included. The mean ONSD value was 3.30 ± 0.27 mm in the right eye and 3.30 ± 0.23 mm in the left eye, with no significant difference between both eyes (p = 0.797). Male neonates had a larger ONSD than female neonates (3.34 ± 0.22 mm versus 3.26 ± 0.20 mm, p = 0.007), and ONSD was correlated with birth weight in the males. Otherwise, there were no statistically significant associations between ONSD and other birth characteristics in both sexes. Most (63%) cases were followed for at least 12 months, and 98% had normal neurodevelopment. Conclusion: The reference value reported in this study may be used to evaluate the ONSD in healthy term neonates. Sex differences should be considered in this age group.
UR - http://www.scopus.com/inward/record.url?scp=85109081731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85109081731&partnerID=8YFLogxK
U2 - 10.1016/j.pedneo.2021.05.021
DO - 10.1016/j.pedneo.2021.05.021
M3 - Article
C2 - 34226155
AN - SCOPUS:85109081731
VL - 62
SP - 591
EP - 597
JO - Acta Paediatrica Sinica
JF - Acta Paediatrica Sinica
SN - 1875-9572
IS - 6
ER -