Measurement of synovial tumor necrosis factor-alpha in diagnosing emergency patients with bacterial arthritis

Geng Wang Jeng, Chrong Reen Wang, Shyh Tsair Liu, Che Chun Su, Rong Tai Tsai, Tsann Sheng Yeh, Chia Lin Wen, Yea Quey Wu, Chang Yu Lin, Gwon Loon Lee, Mao Yuan Chen, Ming Fei Liu, Che Yen Chuang, Cheng Yen Chen

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Abstract

Because of the high morbidity and mortality in patients with bacterial arthritis, rapidly and correctly diagnosing this critical condition is a challenge to emergency clinicians. Synovial fluid samples were obtained from 75 patients with arthritis disorders who presented to an emergency service, and levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL- 1β), and interleukin-6 (IL-6) were measured. Twenty patients with culture- proven bacterial arthritis had, higher levels of synovial TNF-α than patients with osteoarthritis or with inflammatory arthritis, including gouty arthritis, rheumatoid arthritis, reactive arthritis, and lupus arthritis. There was a good sensitivity for synovial TNF-α level in diagnosing patients with bacterial arthritis. Nearly 100% of patients with bacterial arthritis had elevated synovial TNF-α levels. However, synovial IL-1β and IL-6 levels failed to discriminate bacterial arthritis from other inflammatory arthritis. Measurement of synovial TNF-α level may be useful as a diagnostic aid in emergency patients with bacterial arthritis disorders.

Original languageEnglish
Pages (from-to)626-629
Number of pages4
JournalAmerican Journal of Emergency Medicine
Volume15
Issue number7
DOIs
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Emergency Medicine

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    Jeng, G. W., Wang, C. R., Liu, S. T., Su, C. C., Tsai, R. T., Yeh, T. S., Wen, C. L., Wu, Y. Q., Lin, C. Y., Lee, G. L., Chen, M. Y., Liu, M. F., Chuang, C. Y., & Chen, C. Y. (1997). Measurement of synovial tumor necrosis factor-alpha in diagnosing emergency patients with bacterial arthritis. American Journal of Emergency Medicine, 15(7), 626-629. https://doi.org/10.1016/S0735-6757(97)90173-X