Mechanical evaluation of topical silicone gel on skin wound healing

C. H. Chiang, C. S. Yang, C. H. Yeh, M. Y. Chen, Fong-chin Su, C. Y. Liu, C. Y. Chen, Ming-Long Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

Original languageEnglish
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
DOIs
Publication statusPublished - 2009 Sep 21
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: 2009 Apr 32009 Apr 5

Publication series

NameBioengineering, Proceedings of the Northeast Conference
ISSN (Print)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
CountryUnited States
CityBoston, MA
Period09-04-0309-04-05

Fingerprint

Silicone Gels
Silicones
Skin
Gels
Recovery
Collagen
Hydration
Rats
Tensile strength
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Chiang, C. H., Yang, C. S., Yeh, C. H., Chen, M. Y., Su, F., Liu, C. Y., ... Yeh, M-L. (2009). Mechanical evaluation of topical silicone gel on skin wound healing. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference [4967834] (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967834
Chiang, C. H. ; Yang, C. S. ; Yeh, C. H. ; Chen, M. Y. ; Su, Fong-chin ; Liu, C. Y. ; Chen, C. Y. ; Yeh, Ming-Long. / Mechanical evaluation of topical silicone gel on skin wound healing. NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. (Bioengineering, Proceedings of the Northeast Conference).
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Chiang, CH, Yang, CS, Yeh, CH, Chen, MY, Su, F, Liu, CY, Chen, CY & Yeh, M-L 2009, Mechanical evaluation of topical silicone gel on skin wound healing. in NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference., 4967834, Bioengineering, Proceedings of the Northeast Conference, IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009, Boston, MA, United States, 09-04-03. https://doi.org/10.1109/NEBC.2009.4967834

Mechanical evaluation of topical silicone gel on skin wound healing. / Chiang, C. H.; Yang, C. S.; Yeh, C. H.; Chen, M. Y.; Su, Fong-chin; Liu, C. Y.; Chen, C. Y.; Yeh, Ming-Long.

NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967834 (Bioengineering, Proceedings of the Northeast Conference).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Yang, C. S.

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AU - Chen, M. Y.

AU - Su, Fong-chin

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AU - Chen, C. Y.

AU - Yeh, Ming-Long

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N2 - Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

AB - Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

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Chiang CH, Yang CS, Yeh CH, Chen MY, Su F, Liu CY et al. Mechanical evaluation of topical silicone gel on skin wound healing. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. 2009. 4967834. (Bioengineering, Proceedings of the Northeast Conference). https://doi.org/10.1109/NEBC.2009.4967834