Mechanical evaluation of topical silicone gel on skin wound healing

C. H. Chiang, C. S. Yang, C. H. Yeh, M. Y. Chen, F. C. Su, C. Y. Liu, C. Y. Chen, M. L. Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dermatix is a Food and Drug Administration (FDA) registered treatment for hypertrophic scars and keloids. Some studies have evaluated its effects on scars and tried to find out its mechanism of effectiveness. However, there were few papers discussing about the mechanical properties of wounds after treated with Dermatix. Thus, our study aims to conduct tensile test to analyze the condition of skin wound treated with Dermatix and compare the results to the non-treated wounds. We evaluated the wound healing condition at 1, 2, 4 and 6 weeks healing time and introduced recovery index to normalize the different growing condition of each rats. The results showed that during healing time 4-6 weeks, both wounds recovered rapidly. And in all the healing time, Dermatix treated group showed better tensile strength and better recovery index. However, no significant difference was found at all healing time. We guess it is occlusion, hydration and normalization of TEWL effects of Dermatix that help collagen synthesize.

Original languageEnglish
Title of host publicationNEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781424443628
DOIs
Publication statusPublished - 2009
EventIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States
Duration: 2009 Apr 32009 Apr 5

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X

Other

OtherIEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Country/TerritoryUnited States
CityBoston, MA
Period09-04-0309-04-05

All Science Journal Classification (ASJC) codes

  • Bioengineering

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