Mechanical properties and biomedical application characteristics of degradable polylactic acid–Mg–Ca3(PO4)2 three-phase composite

Kuan-Jen Chen, Fei Yi Hung, Yun Ting Wang, Chen Wei Yen

Research output: Contribution to journalArticlepeer-review

Abstract

Polylactic acid (PLA), pure magnesium powder, and calcium phosphate powder were used to form a three-phase degradable biomedical composite. The effects of various powder proportions in polylactic acid–Mg–Ca3(PO4)2 composites were analyzed through mechanical and biological tests, which revealed that both the tensile and impact strength of the composite increased. Additionally, ductility presented only after a small proportion of powder was added. Hardness slightly increased because of dispersion strengthening. Furthermore, the addition of pure magnesium and calcium phosphate accelerated the degradation rate, and biocompatible salts were generated after degradation, which can improve healing and renewal in bone tissue. None of the composites exhibited cytotoxicity, meeting biological safety requirements. Overall, PLA10M10C (10 wt.% Mg, 10 wt.% Ca3(PO4)2) exhibited superior performance. Accordingly, PLA10M10C can serve as a reference for degradable biomedical material applications in orthopedic implants.

Original languageEnglish
Article number104949
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume125
DOIs
Publication statusPublished - 2022 Jan

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

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