TY - JOUR
T1 - Mechanical properties and biomedical application characteristics of degradable polylactic acid–Mg–Ca3(PO4)2 three-phase composite
AU - Chen, Kuan Jen
AU - Hung, Fei Yi
AU - Wang, Yun Ting
AU - Yen, Chen Wei
N1 - Funding Information:
The authors thank the Ministry of Science and Technology, Taiwan , for financially supporting this study under grant number MOST 109-2221-E-006-132-MY2. The authors also thank Ting Sin Co., Ltd. for assistance in obtaining the material. This manuscript was edited by Wallace Academic Editing.
Funding Information:
The authors thank the Ministry of Science and Technology, Taiwan, for financially supporting this study under grant number MOST 109-2221-E-006-132-MY2. The authors also thank Ting Sin Co. Ltd. for assistance in obtaining the material. This manuscript was edited by Wallace Academic Editing.
Publisher Copyright:
© 2021
PY - 2022/1
Y1 - 2022/1
N2 - Polylactic acid (PLA), pure magnesium powder, and calcium phosphate powder were used to form a three-phase degradable biomedical composite. The effects of various powder proportions in polylactic acid–Mg–Ca3(PO4)2 composites were analyzed through mechanical and biological tests, which revealed that both the tensile and impact strength of the composite increased. Additionally, ductility presented only after a small proportion of powder was added. Hardness slightly increased because of dispersion strengthening. Furthermore, the addition of pure magnesium and calcium phosphate accelerated the degradation rate, and biocompatible salts were generated after degradation, which can improve healing and renewal in bone tissue. None of the composites exhibited cytotoxicity, meeting biological safety requirements. Overall, PLA10M10C (10 wt.% Mg, 10 wt.% Ca3(PO4)2) exhibited superior performance. Accordingly, PLA10M10C can serve as a reference for degradable biomedical material applications in orthopedic implants.
AB - Polylactic acid (PLA), pure magnesium powder, and calcium phosphate powder were used to form a three-phase degradable biomedical composite. The effects of various powder proportions in polylactic acid–Mg–Ca3(PO4)2 composites were analyzed through mechanical and biological tests, which revealed that both the tensile and impact strength of the composite increased. Additionally, ductility presented only after a small proportion of powder was added. Hardness slightly increased because of dispersion strengthening. Furthermore, the addition of pure magnesium and calcium phosphate accelerated the degradation rate, and biocompatible salts were generated after degradation, which can improve healing and renewal in bone tissue. None of the composites exhibited cytotoxicity, meeting biological safety requirements. Overall, PLA10M10C (10 wt.% Mg, 10 wt.% Ca3(PO4)2) exhibited superior performance. Accordingly, PLA10M10C can serve as a reference for degradable biomedical material applications in orthopedic implants.
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U2 - 10.1016/j.jmbbm.2021.104949
DO - 10.1016/j.jmbbm.2021.104949
M3 - Article
C2 - 34736029
AN - SCOPUS:85118272007
SN - 1751-6161
VL - 125
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
M1 - 104949
ER -