Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives

Dan Jae Lin, Chien-Ping Ju, Shu Huei Huang, Yin Chun Tien, Hsiang Shu Yin, Wen Cheng Chen, Jiin-Huey Chern

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the osteointegration of a titanium (Ti) implant with the calcium phosphate cement (CPC) and autograft prostheses by pull-out test and histological examination. Stems of sixty Ti cylinders were bilaterally inserted into femoral medullary canals in 30 rabbits at the 1st, 4th, 12th, 26th and 70th postoperative weeks. The bone autograft and CPC were filled into the pre-trimmed bone marrow cavity with a polymethyl methacrylate retarder in the distal end, and then a Ti cylinder was inserted into femurs. The CPC group was significantly (p<0.05) associated with a larger pull-out force at 4th (37%) and 12th (62%) weeks compared to the autograft group. The bone area and the bone-to-implant contact ratios of the CPC groups were significantly higher than that of the autograft groups at early healing stage. The histological exams suggest that the CPC enhanced the earlier bone formation around the implant at a period not longer than 12 weeks postoperation. We conclude that CPC graft has the higher ability to facilitate the osteointegration and stabilize the Ti implant at a relatively early stage than the autograft in vivo.

Original languageEnglish
Pages (from-to)1186-1195
Number of pages10
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume4
Issue number7
DOIs
Publication statusPublished - 2011 Oct 1

Fingerprint

Bone cement
Bone Cements
Mechanical testing
Autografts
Calcium phosphate
Titanium
Cements
Bone
Canals
Polymethyl Methacrylate
Prosthetics
Polymethyl methacrylates
Grafts
calcium phosphate

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

Cite this

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title = "Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives",
abstract = "The purpose of this study was to evaluate the osteointegration of a titanium (Ti) implant with the calcium phosphate cement (CPC) and autograft prostheses by pull-out test and histological examination. Stems of sixty Ti cylinders were bilaterally inserted into femoral medullary canals in 30 rabbits at the 1st, 4th, 12th, 26th and 70th postoperative weeks. The bone autograft and CPC were filled into the pre-trimmed bone marrow cavity with a polymethyl methacrylate retarder in the distal end, and then a Ti cylinder was inserted into femurs. The CPC group was significantly (p<0.05) associated with a larger pull-out force at 4th (37{\%}) and 12th (62{\%}) weeks compared to the autograft group. The bone area and the bone-to-implant contact ratios of the CPC groups were significantly higher than that of the autograft groups at early healing stage. The histological exams suggest that the CPC enhanced the earlier bone formation around the implant at a period not longer than 12 weeks postoperation. We conclude that CPC graft has the higher ability to facilitate the osteointegration and stabilize the Ti implant at a relatively early stage than the autograft in vivo.",
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Mechanical testing and osteointegration of titanium implant with calcium phosphate bone cement and autograft alternatives. / Lin, Dan Jae; Ju, Chien-Ping; Huang, Shu Huei; Tien, Yin Chun; Yin, Hsiang Shu; Chen, Wen Cheng; Chern, Jiin-Huey.

In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 4, No. 7, 01.10.2011, p. 1186-1195.

Research output: Contribution to journalArticle

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