Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide

Sheng Yow Ho, Po Chang Huang, How Ran Guo, Wen Huei Chang, Rong Jane Chen, Bai Lu Wei, Wei Jr Wu, Chein Tai, Ying Jan Wang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Apoptosis is a common mode of cell death after exposure of tumor cells to radiation and/or chemotherapy. The factors that determine the rate of induction of apoptosis are generally related to the functioning of cell cycle checkpoints. In the present study, we investigated the involvement of several genes in cell cycle redistribution and induction of apoptosis in U937 cells after low and high doses of radiation. Activation of CDC2 was observed after both low and high doses of radiation in U937 cells that underwent apoptosis. Expression of CDK2, CDC2 and cyclin A was induced rapidly in the process of radiation-induced apoptosis. In addition, we investigated the use of a clinically relevant dose of radiation to promote As2O3-induced apoptosis in U937 cells. We found that combining radiation and As2O3 may be a new and more effective means of Cancer treatment.

Original languageEnglish
Pages (from-to)390-399
Number of pages10
JournalRadiation Research
Volume165
Issue number4
DOIs
Publication statusPublished - 2006 Apr

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging

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