Mechanoregulation of cell function

Yang Kao Wang, Rowena McBeath, Nathan J. Sniadecki, John L. Tan, Dana M. Pirone, Christopher S. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The binding of cell surface receptors to soluble and insoluble adhesive factors is the principal mechanism by which cells survey their microenvironment and accordingly modulate behaviors such as proliferation, differentiation, migration, and apoptosis. Using microfabrication approaches to engineer cellular microenvironments, we are examining how adhesive and soluble cues cooperate to control basic processes such as endothelial cell proliferation, or the commitment and differentiation of human mesenchymal stem cells to a variety of lineage fates. Here, we describe the approaches we have used to reveal that adhesion appears to exert its effects by modulating mechanochemical signals that regulate actin cytoskeletal tension. This tension appears to be central to driving the lineage commitment process. These studies suggest that mechanical stress generated within cells appears to be a central regulator of cellular function shared among many types of cells.

Original languageEnglish
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Pages904-905
Number of pages2
Publication statusPublished - 2005 Dec 1
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: 2005 Jun 222005 Jun 26

Publication series

NameProceedings of the 2005 Summer Bioengineering Conference
Volume2005

Other

Other2005 Summer Bioengineering Conference
CountryUnited States
CityVail, CO
Period05-06-2205-06-26

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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