Melatonin prevents chronic kidney disease-induced hypertension in young rat treated with adenine: Implications of gut microbiota-derived metabolites

Agriculture & Biology

• kidney diseases 96%
• adenine 81%
• hypertension 81%
• intestinal microorganisms 76%
• trimethylamine 64%
• metabolites 50%
• rats 39%
• oxides 31%
• kidneys 24%
• gender 20%
• therapeutics 19%
• nitric oxide 15%
• Roseburia 14%
• toxins 13%
• nitric oxide synthase 9%
• Proteobacteria 9%
• hypertrophy 9%
• diet 8%
• drinking water 8%
• protective effect 8%
• animal models 7%
• hormones 5%

Medicine & Life Sciences

• Adenine 89%
• Melatonin 82%
• Chronic Renal Insufficiency 69%
• Hypertension 49%
• N,N-dimethylarginine 47%
• Nitric Oxide 13%
• Kidney 13%
• Diet 11%
• Safe Sex 11%
• Proteobacteria 11%
• Renal Hypertension 10%
• Kidney Diseases 8%
• Insurance Benefits 8%
• Drinking Water 8%
• Wounds and Injuries 8%
• Nitric Oxide Synthase 8%
• Hypertrophy 7%
• Sprague Dawley Rats 7%
• Hormones 5%
• Therapeutics 4%

Chemical Compounds

• Melatonin 100%
• Adenine 70%
• Dimethylarginine 56%
• Metabolite 53%
• Trimethylamine N-Oxide 36%
• Uremic Toxin 27%
• Nitric Oxide 16%
• Nitric Oxide Synthase Inhibitor 12%
• Trimethylamine 10%
• Drinking Water 8%
• Hormone 8%
• Disorder 7%
• Protective 7%
• Plasma 5%