TY - JOUR
T1 - Memory for gist and detail information in patients with Parkinson's disease
AU - Yu, Rwei Ling
AU - Tan, Chun Hsiang
AU - Wu, Yih Ru
AU - Wu, Ruey Meei
AU - Chiu, Ming Jang
AU - Hua, Mau Sun
N1 - Funding Information:
3Department of Neurology, Chang Gung Memorial Hospital-Linkou Branch, Chang Gung University College of Medicine, Taoyuan, Taiwan 4Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan 5Department of Psychology, National Taiwan University, Taipei, Taiwan 6Department of Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan 7Department of Psychiatry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan 8Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan Acknowledgements The authors are grateful to the participants involved in this study, and for the grant from the Ministry of Science and Technology (MOST), Taipei, Taiwan (MOST 103-2410-H-006-120-MY2, MOST 103-2633-H-006-001 and MOST 104-2633-H-006 -001). The authors declare no conflict of interest.
Publisher Copyright:
© 2015 BMJ Publishing Group. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Objective: Memory formation is proposed to be a dual process that involves the simultaneous memorisation of both detailed information (item-specific memory) and gist information (gist memory). Memory deficits have been reported in patients with Parkinson's disease (PD); however, few studies have explicitly addressed the nature of these deficits. To obtain a detailed understanding of memory dysfunction in patients with PD, it is of crucial importance to establish whether item-specific memory and gist memory performance are impaired. The aim of this study is to explore whether gist memory and item-specific memory performance are still intact in patients with PD, as well as to determine which psychological mechanisms are responsible for memory formation. Setting: Two hospitals in northern Taiwan. Participants: Thirty-nine patients with PD and 28 normal controls were recruited. Each participant received a gist-based recognition test following the Deese-Roediger-McDermott paradigm, as well as neuropsychological tests and measures of clinical characteristics. Results: Gist memory was impaired in patients with advanced-stage disease (Hoehn and Yahr (H&Y) stage: III) (F2, 64=3.58, p=0.033), whereas item-specific memory was preserved throughout all disease stages. Correlation analysis showed that item-specific memory was related to executive functions in normal controls and early-stage patients with PD (H&Y stage: I-II); however, item-specific memory was related to episodic memory, rather than to executive functions, in advanced-stage patients with PD. Moreover, gist memory was related to episodic memory, but only in early-stage patients with PD. Conclusions: We discovered that impaired gist memory is found in advanced-stage, but not in early-stage, patients with PD. Our findings suggest that the techniques used to take advantage of the relatively preserved gist memory in early-stage patients with PD, as well as the preserved item-specific memory in patients with PD of all stages, could be useful for memory rehabilitation programmes.
AB - Objective: Memory formation is proposed to be a dual process that involves the simultaneous memorisation of both detailed information (item-specific memory) and gist information (gist memory). Memory deficits have been reported in patients with Parkinson's disease (PD); however, few studies have explicitly addressed the nature of these deficits. To obtain a detailed understanding of memory dysfunction in patients with PD, it is of crucial importance to establish whether item-specific memory and gist memory performance are impaired. The aim of this study is to explore whether gist memory and item-specific memory performance are still intact in patients with PD, as well as to determine which psychological mechanisms are responsible for memory formation. Setting: Two hospitals in northern Taiwan. Participants: Thirty-nine patients with PD and 28 normal controls were recruited. Each participant received a gist-based recognition test following the Deese-Roediger-McDermott paradigm, as well as neuropsychological tests and measures of clinical characteristics. Results: Gist memory was impaired in patients with advanced-stage disease (Hoehn and Yahr (H&Y) stage: III) (F2, 64=3.58, p=0.033), whereas item-specific memory was preserved throughout all disease stages. Correlation analysis showed that item-specific memory was related to executive functions in normal controls and early-stage patients with PD (H&Y stage: I-II); however, item-specific memory was related to episodic memory, rather than to executive functions, in advanced-stage patients with PD. Moreover, gist memory was related to episodic memory, but only in early-stage patients with PD. Conclusions: We discovered that impaired gist memory is found in advanced-stage, but not in early-stage, patients with PD. Our findings suggest that the techniques used to take advantage of the relatively preserved gist memory in early-stage patients with PD, as well as the preserved item-specific memory in patients with PD of all stages, could be useful for memory rehabilitation programmes.
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U2 - 10.1136/BMJOPEN-2015-009795
DO - 10.1136/BMJOPEN-2015-009795
M3 - Article
C2 - 26589429
AN - SCOPUS:85021858812
SN - 2044-6055
VL - 5
JO - BMJ Open
JF - BMJ Open
IS - 11
M1 - e009795
ER -