Abstract
In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO 2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.
| Original language | English |
|---|---|
| Article number | 1700628 |
| Journal | Advanced Functional Materials |
| Volume | 27 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - 2017 Jul 12 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Materials Science(all)
- Condensed Matter Physics
Cite this
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Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing. / Song, Yang; Lin, Zaifu; Kong, Lingqing; Xing, Yao; Lin, Naibo; Zhang, Zhisen; Chen, Bing-Hung; Liu, Xiang Yang.
In: Advanced Functional Materials, Vol. 27, No. 26, 1700628, 12.07.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing
AU - Song, Yang
AU - Lin, Zaifu
AU - Kong, Lingqing
AU - Xing, Yao
AU - Lin, Naibo
AU - Zhang, Zhisen
AU - Chen, Bing-Hung
AU - Liu, Xiang Yang
PY - 2017/7/12
Y1 - 2017/7/12
N2 - In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO 2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.
AB - In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO 2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.
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U2 - 10.1002/adfm.201700628
DO - 10.1002/adfm.201700628
M3 - Article
VL - 27
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 26
M1 - 1700628
ER -