TY - JOUR
T1 - Meso-Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing
AU - Song, Yang
AU - Lin, Zaifu
AU - Kong, Lingqing
AU - Xing, Yao
AU - Lin, Naibo
AU - Zhang, Zhisen
AU - Chen, Bing Hung
AU - Liu, Xiang Yang
N1 - Funding Information:
The work was supported by the 111 Project (Grant No. B16029), National Natural Science Foundation of China (Grant Nos. 21404087, 61674050, and U1405226), Fujian Provincial Department of Science and Technology (Grant Nos. 2017J06019, 2014H6022, and 2015J05109), Natural Science Foundation of Guangdong Province (Grant No. 2015A030310007), 1000 Talents Program, and President Foundation from Xiamen University (Grant No. 20720160088), NUS tear 1 funding (WBS: R-144-000-367-112). One of the authors, X.-Y.Liu's primary affiliation is Department of Physics, National University of Singapore.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/7/12
Y1 - 2017/7/12
N2 - In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.
AB - In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.
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U2 - 10.1002/adfm.201700628
DO - 10.1002/adfm.201700628
M3 - Article
AN - SCOPUS:85018309447
VL - 27
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 26
M1 - 1700628
ER -