@article{a3979118cb844cb48fc6c12afe092e3f,
title = "Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE",
abstract = "In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.",
author = "Raimondo, {Joseph V.} and Uwe Heinemann and {de Curtis}, Marco and Goodkin, {Howard P.} and Dulla, {Chris G.} and Damir Janigro and Akio Ikeda and Lin, {Chou Ching K.} and Premysl Jiruska and Galanopoulou, {Aristea S.} and Christophe Bernard",
note = "Funding Information: This article is dedicated to the memory of the late Uwe Heinemann, a fantastic scientist, mentor, and friend. We thank the members of the TASK1 and the AES/ILAE Translational Task Force of the International League Against Epilepsy (ILAE), in particular Norberto Garcia Cairasco and Miguel Angel Cortez, for critical reading and comments on preliminary versions of the manuscript. We also would like to acknowledge Lauren-Harte-Hargrove for assistance during the preparation of the manuscript. J.V.R. was supported by a Royal Society Newton Advanced Fellowship and grant support from the Blue Brain Project. Chris G. Dulla was supported by a grant from the National Institute of Neurological Disease and Stroke (NINDS) R01-NS076885 and the CURE Infantile Spasms Initiative. Premysl Jiruska was supported by grants from the Neuron Fund for Support of Science (001/2012), the Ministry of Health of the Czech Republic (15-29835A, 15-33115A), and the Czech Science Foundation (14-02634S, 14-11345S). Aristea S. Galanopoulou acknowledges grant support by NINDS RO1 NS091170 and U54 NS100064, the U.S. Department of Defense (W81XWH-13-1-0180), and the CURE Infantile Spasms Initiative, and research funding from the Heffer Family and the Segal Family Foundations and the Abbe Goldstein/Joshua Lurie and Laurie Marsh/Dan Levitz families. Christophe Bernard was supported by National Agency for Research ANR-13-NEUC-0005 Motion. We are also grateful to the American Epilepsy Society (AES) and ILAE for partially sponsoring the activities of the AES/ILAE Translational Task Force of the ILAE. Publisher Copyright: Wiley Periodicals, Inc. {\textcopyright} 2017 International League Against Epilepsy",
year = "2017",
month = nov,
doi = "10.1111/epi.13901",
language = "English",
volume = "58",
pages = "40--52",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
}