Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE

Joseph V. Raimondo, Uwe Heinemann, Marco de Curtis, Howard P. Goodkin, Chris G. Dulla, Damir Janigro, Akio Ikeda, Chou Ching K. Lin, Premysl Jiruska, Aristea S. Galanopoulou, Christophe Bernard

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity.

Original languageEnglish
Pages (from-to)40-52
Number of pages13
JournalEpilepsia
Volume58
DOIs
Publication statusPublished - 2017 Nov

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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