Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression

Wei-Li Wu, Y. W. Lin, M. Y. Min, C. C. Chen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Sensing external stimulation is crucial for central processing in the brain and subsequent behavioral expression. Although sensory alteration or deprivation may result in behavioral changes, most studies related to the control of behavior have focused on central mechanisms. Here we created a sensory deficit model of mice lacking acid-sensing ion channel 3 (Asic3 -/-) to probe behavioral alterations. ASIC3 is predominately distributed in the peripheral nervous system. RT-PCR and immunohistochemistry used to examine the expression of Asic3 in the mouse brain showed near-background mRNA and protein levels of ASIC3 throughout the whole brain, except for the sensory mesencephalic trigeminal nucleus. Consistent with the expression results, Asic3 knockout had no effect on synaptic plasticity of the hippocampus and the behavioral tasks of motor function, learning and memory. In anxiety behavior tasks, Asic3-/- mice spent more time in the open arms of an elevated plus maze than did their wild-type littermates. Asic3 -/- mice also displayed less aggressiveness toward intruders but more stereotypic repetitive behaviors during resident-intruder testing than did wild-type littermates. Therefore, loss of ASIC3 produced behavioral changes in anxiety and aggression in mice, which suggests that ASIC3-dependent sensory activities might relate to the central process of emotion modulation.

Original languageEnglish
Pages (from-to)603-614
Number of pages12
JournalGenes, Brain and Behavior
Volume9
Issue number6
DOIs
Publication statusPublished - 2010 Aug 1

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Aggression
Anxiety
Brain
Tegmentum Mesencephali
Neuronal Plasticity
Behavior Control
Peripheral Nervous System
Hippocampus
Emotions
Immunohistochemistry
Learning
Polymerase Chain Reaction
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

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Mice lacking Asic3 show reduced anxiety-like behavior on the elevated plus maze and reduced aggression. / Wu, Wei-Li; Lin, Y. W.; Min, M. Y.; Chen, C. C.

In: Genes, Brain and Behavior, Vol. 9, No. 6, 01.08.2010, p. 603-614.

Research output: Contribution to journalArticle

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