Microencapsulation of dual-release plga microparticle for curcumin and doxorubicin released in stages

Szu I. Yeh, Kai Hsiang Yang, Jing Tang Yang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we proposed a microdroplet-based fabrication concept of a composited PLGA-based dual-drug release microparticle loaded with curcumin and doxorubicin. We used sodium bicarbonate (NaHCO3) as the porogen to form the porous structure in PLGA microparticles and filled the sodium alginate into the pores of PLGA microparticles. The dual-release of curcumin and doxorubicin would decrease the cardiotoxicity of chemotherapy drugs which is highly serviceable in cancer therapeutics and the clinical management of intractable diseases.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages835-837
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - 2015 Jan 1
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 2015 Oct 252015 Oct 29

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period15-10-2515-10-29

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Yeh, S. I., Yang, K. H., & Yang, J. T. (2015). Microencapsulation of dual-release plga microparticle for curcumin and doxorubicin released in stages. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 835-837). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.