TY - JOUR
T1 - Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules
AU - Huang, Keng Shiang
AU - Lu, Kang
AU - Yeh, Chen Sheng
AU - Chung, Shu Ru
AU - Lin, Che Hsin
AU - Yang, Chih Hui
AU - Dong, Yu Shun
N1 - Funding Information:
This work was supported by a grant from the National Science Council of Taiwan. (97-2320-B-214-002-MY3 and 97-2314-B-214-004).
PY - 2009/7/1
Y1 - 2009/7/1
N2 - This paper demonstrates a proof-of-concept approach for producing genipin-gelatin microcapsules of precisely controlled and monodisperse size distributions by the microfluidic channels. We have demonstrated that one could control the size of emulsions from 130 μm to 580 μm in diameter (with a variation of less than 5%) by altering the relative sheath/sample flow rate ratio. In addition, Results show that the encapsulation and in vitro release of a model drug, 5-fluorouracil, to enhance the effect of controlled release. We demonstrated that the appropriate particle size for different release patterns is predictable, enabling better application of genipin-gelatin microcapsules as a drug carrier. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets with well controllable diameter, and it has the added advantages of being a simple, low cost, and high throughput process. Crown
AB - This paper demonstrates a proof-of-concept approach for producing genipin-gelatin microcapsules of precisely controlled and monodisperse size distributions by the microfluidic channels. We have demonstrated that one could control the size of emulsions from 130 μm to 580 μm in diameter (with a variation of less than 5%) by altering the relative sheath/sample flow rate ratio. In addition, Results show that the encapsulation and in vitro release of a model drug, 5-fluorouracil, to enhance the effect of controlled release. We demonstrated that the appropriate particle size for different release patterns is predictable, enabling better application of genipin-gelatin microcapsules as a drug carrier. The proposed microfluidic chip is capable of generating relatively uniform micro-droplets with well controllable diameter, and it has the added advantages of being a simple, low cost, and high throughput process. Crown
UR - http://www.scopus.com/inward/record.url?scp=67349199958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349199958&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2009.02.019
DO - 10.1016/j.jconrel.2009.02.019
M3 - Article
C2 - 19264103
AN - SCOPUS:67349199958
SN - 0168-3659
VL - 137
SP - 15
EP - 19
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -