Microfluidic distillation chip for methanol concentration detection

Yao Nan Wang, Chan Chiung Liu, Ruey Jen Yang, Wei Jhong Ju, Lung Ming Fu

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


An integrated microfluidic distillation system is proposed for separating a mixed ethanol-methanol-water solution into its constituent components. The microfluidic chip is fabricated using a CO2 laser system and comprises a serpentine channel, a boiling zone, a heating zone, and a cooled collection chamber filled with de-ionized (DI) water. In the proposed device, the ethanol-methanol-water solution is injected into the microfluidic chip and driven through the serpentine channel and into the collection chamber by means of a nitrogen carrier gas. Following the distillation process, the ethanol-methanol vapor flows into the collection chamber and condenses into the DI water. The resulting solution is removed from the collection tank and reacted with a mixed indicator. Finally, the methanol concentration is inversely derived from the absorbance measurements obtained using a spectrophotometer. The experimental results show the proposed microfluidic system achieves an average methanol distillation efficiency of 97%. The practicality of the proposed device is demonstrated by detecting the methanol concentrations of two commercial fruit wines. It is shown that the measured concentration values deviate by no more than 3% from those obtained using a conventional bench top system.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalAnalytica Chimica Acta
Publication statusPublished - 2016 Mar 17

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy


Dive into the research topics of 'Microfluidic distillation chip for methanol concentration detection'. Together they form a unique fingerprint.

Cite this