Microfluidic mixing: A review

Chia Yen Lee, Chin Lung Chang, Yao Nan Wang, Lung Ming Fu

Research output: Contribution to journalReview articlepeer-review

626 Citations (Scopus)


The aim of microfluidic mixing is to achieve a thorough and rapid mixing of multiple samples in microscale devices. In such devices, sample mixing is essentially achieved by enhancing the diffusion effect between the different species flows. Broadly speaking, microfluidic mixing schemes can be categorized as either "active", where an external energy force is applied to perturb the sample species, or "passive", where the contact area and contact time of the species samples are increased through specially-designed microchannel configurations. Many mixers have been proposed to facilitate this task over the past 10 years. Accordingly, this paper commences by providing a high level overview of the field of microfluidic mixing devices before describing some of the more significant proposals for active and passive mixers.

Original languageEnglish
Pages (from-to)3263-3287
Number of pages25
JournalInternational journal of molecular sciences
Issue number5
Publication statusPublished - 2011 May

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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