TY - GEN
T1 - Microfluidic system for rapid detection of influenza infection by utilizing magnetic MnFe 2O 4 nanoparticle-based immunoassay
AU - Hung, Lien Yu
AU - Cheng, Fong Yu
AU - Huang, Chih Chia
AU - Tsai, Yi Che
AU - Yeh, Chen Sheng
AU - Lei, Huan Yao
AU - Lee, Gwo Bin
PY - 2012/6/1
Y1 - 2012/6/1
N2 - In this study, new magnetic manganese ferrite (MnFe 2O 4) nanoparticles with a size around 100 nanometer (nm) in diameter were used to improve the performance of an immunoassay for detection of influenza infection. A new microfluidic system was developed to implement the detection process. In order to apply these new nanoparticles for influenza detection, the design of the micromixer was modified to reduce the dead volume. Furthermore, the operating condition for the magnet was optimized such that magnetic MnFe 2O 4 nanoparticles can be collected in 120 seconds. The optical signals showed this nanoparticle-based immunoassay could successfully distinguish the virus sample from the negative control sample. This developed microfluidic system can automatically perform the entire process involved in the immunoassay, including virus purification and detection, and therefore may provide a promising platform for fast diagnosis of the infectious diseases.
AB - In this study, new magnetic manganese ferrite (MnFe 2O 4) nanoparticles with a size around 100 nanometer (nm) in diameter were used to improve the performance of an immunoassay for detection of influenza infection. A new microfluidic system was developed to implement the detection process. In order to apply these new nanoparticles for influenza detection, the design of the micromixer was modified to reduce the dead volume. Furthermore, the operating condition for the magnet was optimized such that magnetic MnFe 2O 4 nanoparticles can be collected in 120 seconds. The optical signals showed this nanoparticle-based immunoassay could successfully distinguish the virus sample from the negative control sample. This developed microfluidic system can automatically perform the entire process involved in the immunoassay, including virus purification and detection, and therefore may provide a promising platform for fast diagnosis of the infectious diseases.
UR - http://www.scopus.com/inward/record.url?scp=84861555610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861555610&partnerID=8YFLogxK
U2 - 10.1109/NEMS.2012.6196756
DO - 10.1109/NEMS.2012.6196756
M3 - Conference contribution
AN - SCOPUS:84861555610
SN - 9781467311243
T3 - 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
SP - 200
EP - 203
BT - 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
T2 - 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
Y2 - 5 March 2012 through 8 March 2012
ER -
