Microfluidic system for rapid detection of influenza infection by utilizing magnetic MnFe 2O 4 nanoparticle-based immunoassay

Lien Yu Hung, Fong Yu Cheng, Chih Chia Huang, Yi Che Tsai, Chen Sheng Yeh, Huan Yao Lei, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, new magnetic manganese ferrite (MnFe 2O 4) nanoparticles with a size around 100 nanometer (nm) in diameter were used to improve the performance of an immunoassay for detection of influenza infection. A new microfluidic system was developed to implement the detection process. In order to apply these new nanoparticles for influenza detection, the design of the micromixer was modified to reduce the dead volume. Furthermore, the operating condition for the magnet was optimized such that magnetic MnFe 2O 4 nanoparticles can be collected in 120 seconds. The optical signals showed this nanoparticle-based immunoassay could successfully distinguish the virus sample from the negative control sample. This developed microfluidic system can automatically perform the entire process involved in the immunoassay, including virus purification and detection, and therefore may provide a promising platform for fast diagnosis of the infectious diseases.

Original languageEnglish
Title of host publication2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
Pages200-203
Number of pages4
DOIs
Publication statusPublished - 2012 Jun 1
Event7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012 - Kyoto, Japan
Duration: 2012 Mar 52012 Mar 8

Publication series

Name2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012

Other

Other7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
CountryJapan
CityKyoto
Period12-03-0512-03-08

All Science Journal Classification (ASJC) codes

  • Engineering (miscellaneous)

Fingerprint Dive into the research topics of 'Microfluidic system for rapid detection of influenza infection by utilizing magnetic MnFe <sub>2</sub>O <sub>4</sub> nanoparticle-based immunoassay'. Together they form a unique fingerprint.

Cite this