Microfluidic systems for fast and accurate diagnosis of ovarian cancers

Yi Cheng Tsai; Wei Ting Liu; Sheng Po Haung; Wen Bin Lee; Yuan Jhe Chuang; Keng Fu Hsu; Gwo Bin Lee

doi:10.1109/NEMS.2019.8915587

Microfluidic systems for fast and accurate diagnosis of ovarian cancers

Yi Cheng Tsai, Wei Ting Liu, Sheng Po Haung, Wen Bin Lee, Yuan Jhe Chuang, Keng Fu Hsu, Gwo Bin Lee

Department of Obstetrics Gynecology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.

Original language	English
Title of host publication	Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	39-43
Number of pages	5
ISBN (Electronic)	9781728116297
DOIs	https://doi.org/10.1109/NEMS.2019.8915587
Publication status	Published - 2019 Apr
Event	14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 - Bangkok, Thailand Duration: 2019 Apr 11 → 2019 Apr 14

Publication series

Name	Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019

Conference

Conference	14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
Country/Territory	Thailand
City	Bangkok
Period	19-04-11 → 19-04-14

All Science Journal Classification (ASJC) codes

Mechanical Engineering
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/NEMS.2019.8915587

Cite this

Tsai, Y. C., Liu, W. T., Haung, S. P., Lee, W. B., Chuang, Y. J., Hsu, K. F., & Lee, G. B. (2019). Microfluidic systems for fast and accurate diagnosis of ovarian cancers. In Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 (pp. 39-43). Article 8915587 (Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2019.8915587

Tsai, Yi Cheng ; Liu, Wei Ting ; Haung, Sheng Po et al. / Microfluidic systems for fast and accurate diagnosis of ovarian cancers. Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 39-43 (Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019).

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title = "Microfluidic systems for fast and accurate diagnosis of ovarian cancers",

abstract = "Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.",

author = "Tsai, {Yi Cheng} and Liu, {Wei Ting} and Haung, {Sheng Po} and Lee, {Wen Bin} and Chuang, {Yuan Jhe} and Hsu, {Keng Fu} and Lee, {Gwo Bin}",

year = "2019",

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doi = "10.1109/NEMS.2019.8915587",

language = "English",

series = "Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "39--43",

booktitle = "Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019",

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Tsai, YC, Liu, WT, Haung, SP, Lee, WB, Chuang, YJ, Hsu, KF & Lee, GB 2019, Microfluidic systems for fast and accurate diagnosis of ovarian cancers. in Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019., 8915587, Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019, Institute of Electrical and Electronics Engineers Inc., pp. 39-43, 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019, Bangkok, Thailand, 19-04-11. https://doi.org/10.1109/NEMS.2019.8915587

Microfluidic systems for fast and accurate diagnosis of ovarian cancers. / Tsai, Yi Cheng; Liu, Wei Ting; Haung, Sheng Po et al.
Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 39-43 8915587 (Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Tsai, Yi Cheng

AU - Liu, Wei Ting

AU - Haung, Sheng Po

AU - Lee, Wen Bin

AU - Chuang, Yuan Jhe

AU - Hsu, Keng Fu

AU - Lee, Gwo Bin

PY - 2019/4

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N2 - Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.

AB - Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.

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BT - Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019

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ER -

Tsai YC, Liu WT, Haung SP, Lee WB, Chuang YJ, Hsu KF et al. Microfluidic systems for fast and accurate diagnosis of ovarian cancers. In Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 39-43. 8915587. (Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019). doi: 10.1109/NEMS.2019.8915587

Microfluidic systems for fast and accurate diagnosis of ovarian cancers

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