Microfluidic systems for fast and accurate diagnosis of ovarian cancers

Yi Cheng Tsai, Wei Ting Liu, Sheng Po Haung, Wen Bin Lee, Yuan Jhe Chuang, Keng Fu Hsu, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Fast and accurate diagnosis of cancer is challenging. Aptamers may serve as promising artificial antibodies for cancer diagnosis. However, in order to screen highly specific and high-Affinity aptamers targeting specific cancer, it requires a series of complex and lengthy procedures. Furthermore, the screened aptamers may require further optimization for recognizing biomarkers associate with cancer. Moreover, further clinical applications for cancer diagnosis such as immunohistochemistry (IHC) staining is a labor-intensive, time-consuming procedure which requires well-Trained personnel for carrying out the tedious process. In this work, we reported our recent progress on utilizing integrated microfluidic systems to tackle the above issues. Customized flow and temperature control modules have been established to carry out a fast and automated continuous aptamer screening process on a microfluidic chip for screening ovarian cancer (OvCa) specific aptamers targeting plasma membranes of tissues. Another integrated microfluidic platform was also developed for performing the whole process of IHC staining including the sample pretreatment of tissue samples. With these approaches, aptamers may be used for recognizing and detecting clinical tissue samples for OvCa.

Original languageEnglish
Title of host publicationProceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages39-43
Number of pages5
ISBN (Electronic)9781728116297
DOIs
Publication statusPublished - 2019 Apr
Event14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019 - Bangkok, Thailand
Duration: 2019 Apr 112019 Apr 14

Publication series

NameProceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019

Conference

Conference14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019
CountryThailand
CityBangkok
Period19-04-1119-04-14

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Instrumentation

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