MicroRNA as a novel modulator in head and neck squamous carcinoma

Li Hsin Chen, Kun Ling Tsai, Yi Wei Chen, Cheng Chia Yu, Kuo Wei Chang, Shi Hwa Chiou, Hung Hai Ku, Pen Yuan Chu, Ling Ming Tseng, Pin I. Huang, Wen Liang Lo

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in microRNAs have revealed their prominent role in regulating gene expression and provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in head and neck squamous carcinoma. In the present paper, we focus on microRNAs showing significant differences between normal and tumor cells or between cells with differential ability of metastasis. We also emphasize specific microRNAs that could modulate tumor cell properties, such as apoptosis, metastasis, and proliferation. These microRNAs possess the potential to be applied on clinical therapy in the future.

Original languageEnglish
Article number135632
JournalJournal of Oncology
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Oncology


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