TY - JOUR
T1 - Mild chronic kidney disease associated with greater risk of arterial stiffness in elderly adults
AU - Liu, I. Ting
AU - Wu, Jin Shang
AU - Yang, Yi Ching
AU - Huang, Ying Hsiang
AU - Lu, Feng Hwa
AU - Chang, Chih Jen
PY - 2013/10
Y1 - 2013/10
N2 - Objectives To assess the association between arterial stiffness and mild and moderate chronic kidney disease (CKD), independent of other cardiometabolic factors in an elderly population. Design Cross-sectional study. Setting Health examination data from National Cheng Kung University Hospital from 2006 to 2009. Participants Eligible subjects aged 60 and older (N = 1,251). Measurements An average bilateral brachial-ankle pulse wave velocity (baPWV) of 1,400 cm/s or greater was defined as high baPWV. Based on the 2003 Clinical Practice Guidelines for Chronic Kidney Disease from the National Kidney Foundation, mild and moderate CKD were defined as CKD Stages 1 and 2 and Stages 3 to 5, respectively. Results Participants with a baPWV of 1,400 cm/s or greater (n = 1,028) had lower estimated glomerular filtration rates (eGFRs) but higher serum creatinine levels and greater prevalences of mild and moderate CKD, diabetes mellitus, prediabetes mellitus, hypertension, and prehypertension than those with baPWV less than 1,400 cm/s (n = 223). In the multivariate analysis, mild (odds ratio (OR) = 2.58, 95% confidence interval (CI) = 1.02-6.54) and moderate (OR = 3.75, 95% CI = 1.02-13.81) CKD were positively associated with greater baPWV (≥1,400 cm/s). Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also independently associated with greater baPWV. In the multiple linear analysis, moderate (β = 120.45, P <.001) and mild CKD (β = 69.90, P =.01) were positively associated with baPWV. There was also an independently inverse correlation between eGFR and baPWV (β = -0.69, P =.04). Conclusion Mild and moderate CKD increased the risk of greater arterial stiffness in elderly adults. Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also important correlates of increased arterial stiffness.
AB - Objectives To assess the association between arterial stiffness and mild and moderate chronic kidney disease (CKD), independent of other cardiometabolic factors in an elderly population. Design Cross-sectional study. Setting Health examination data from National Cheng Kung University Hospital from 2006 to 2009. Participants Eligible subjects aged 60 and older (N = 1,251). Measurements An average bilateral brachial-ankle pulse wave velocity (baPWV) of 1,400 cm/s or greater was defined as high baPWV. Based on the 2003 Clinical Practice Guidelines for Chronic Kidney Disease from the National Kidney Foundation, mild and moderate CKD were defined as CKD Stages 1 and 2 and Stages 3 to 5, respectively. Results Participants with a baPWV of 1,400 cm/s or greater (n = 1,028) had lower estimated glomerular filtration rates (eGFRs) but higher serum creatinine levels and greater prevalences of mild and moderate CKD, diabetes mellitus, prediabetes mellitus, hypertension, and prehypertension than those with baPWV less than 1,400 cm/s (n = 223). In the multivariate analysis, mild (odds ratio (OR) = 2.58, 95% confidence interval (CI) = 1.02-6.54) and moderate (OR = 3.75, 95% CI = 1.02-13.81) CKD were positively associated with greater baPWV (≥1,400 cm/s). Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also independently associated with greater baPWV. In the multiple linear analysis, moderate (β = 120.45, P <.001) and mild CKD (β = 69.90, P =.01) were positively associated with baPWV. There was also an independently inverse correlation between eGFR and baPWV (β = -0.69, P =.04). Conclusion Mild and moderate CKD increased the risk of greater arterial stiffness in elderly adults. Age, prediabetes mellitus, diabetes mellitus, prehypertension, and hypertension were also important correlates of increased arterial stiffness.
UR - http://www.scopus.com/inward/record.url?scp=84885582372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885582372&partnerID=8YFLogxK
U2 - 10.1111/jgs.12445
DO - 10.1111/jgs.12445
M3 - Article
C2 - 24083328
AN - SCOPUS:84885582372
SN - 0002-8614
VL - 61
SP - 1758
EP - 1762
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 10
ER -