In recent years, with the popularization of mobile network, the location- based service (LBS) has made great strides, becoming an efficient marketing instrument for enterprises. For the retail business, good selections of store and appropriate marketing techniques are critical to increasing the profit. However, it is difficult to select the retail store because there are numerous considerations and the analysis was short of metadata in the past. Therefore, this study uses LBS, and provides a recommendation method for retail store selection by analyzing the relationship between the user track and point-of-interest (POI). This study uses regional relevance analysis and human mobility construction to establish the feature values of retail store recommendation. This study proposes (1) architecture of the data model available for retail store recommendation by influential layers of LBS; (2) System-based solution for recommendation of retail stores, adopts the influential factors with specified data in LBS and filtered by industrial types; (3) Industry density, area categories and region/industry clustering methods of POIs. Uses KDE and KMeans to calculate the effect of regional functionality on the retail store selection, similarity is used to calculate the industry category relation, and consumption capacity is considered to state saturation feature.