MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer

Jhih Kai Pan, Cheng Han Lin, Yao Lung Kuo, Luo Ping Ger, Hui Chuan Cheng, Yun Chin Yao, Michael Hsiao, Pei Jung Lu

Research output: Contribution to journalArticlepeer-review

Abstract

Brian metastasis, which is diagnosed in 30% of triple-negative breast cancer (TNBC) patients with metastasis, causes poor survival outcomes. Growing evidence has characterized miRNAs involving in breast cancer brain metastasis; however, currently, there is a lack of prognostic plasma-based indicator for brain metastasis. In this study, high level of miR-211 can act as brain metastatic prognostic marker in vivo. High miR-211 drives early and specific brain colonization through enhancing trans-blood–brain barrier (BBB) migration, BBB adherence, and stemness properties of tumor cells and causes poor survival in vivo. SOX11 and NGN2 are the downstream targets of miR-211 and negatively regulate miR-211-mediated TNBC brain metastasis in vitro and in vivo. Most importantly, high miR-211 is correlated with poor survival and brain metastasis in TNBC patients. Our findings suggest that miR-211 may be used as an indicator for TNBC brain metastasis.

Original languageEnglish
Pages (from-to)1737-1751
Number of pages15
JournalOncogene
Volume40
Issue number9
DOIs
Publication statusPublished - 2021 Mar 4

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer'. Together they form a unique fingerprint.

Cite this