TY - GEN
T1 - Modeling the marginal distribution of gene expression with mixture models
AU - Wijaya, Edward
AU - Harada, Hajime
AU - Horton, Paul
PY - 2008
Y1 - 2008
N2 - We report the results of fitting mixture models to the distribution of expression values for individual genes over a broad range of normal tissues, which we call the marginal distribution of the gene. The base distributions used were normal, lognormal and gamma. The expectationmaximization algorithm was used to learn the model parameters. Experiments with articifial data were performed to ascertain the robustness of learning. Applying the procedure to data from two publicly available microarray datasets, we conclude that lognormal performed the best function for modeling the marginal distributions of gene expression. Our results should provide guidances in the development of informed priors or gene specific normalization for use with gene network inference algorithms.
AB - We report the results of fitting mixture models to the distribution of expression values for individual genes over a broad range of normal tissues, which we call the marginal distribution of the gene. The base distributions used were normal, lognormal and gamma. The expectationmaximization algorithm was used to learn the model parameters. Experiments with articifial data were performed to ascertain the robustness of learning. Applying the procedure to data from two publicly available microarray datasets, we conclude that lognormal performed the best function for modeling the marginal distributions of gene expression. Our results should provide guidances in the development of informed priors or gene specific normalization for use with gene network inference algorithms.
UR - http://www.scopus.com/inward/record.url?scp=62449242959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62449242959&partnerID=8YFLogxK
U2 - 10.1109/FGCN.2008.75
DO - 10.1109/FGCN.2008.75
M3 - Conference contribution
AN - SCOPUS:62449242959
SN - 9780769534312
T3 - Proceedings of the 2008 2nd International Conference on Future Generation Communication and Networking, FGCN 2008 and BSBT 2008: 2008 International Conference on Bio-Science and Bio-Technology
SP - 84
EP - 89
BT - Proceedings of the 2008 2nd International Conference on Future Generation Communication and Networking, FGCN 2008 and BSBT 2008
T2 - 2008 International Conference on Bio-Science and Bio-Technology, BSBT 2008, held in conjunction with 2008 2nd International Conference on Future Generation Communication and Networking, FGCN 2008
Y2 - 13 December 2008 through 15 December 2008
ER -