Modeling the Maternal Immune Activation Risk Factor for Schizophrenia

Natalia Malkova, Wei-Li Wu, Elaine Y. Hsiao

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Maternal immune activation (MIA) is an important environmental risk factor for schizophrenia. Among various modes of MIA, modeling maternal viral infection by injecting pregnant rodents with the double-stranded RNA polyinosine-polycytidylic yields offspring with strong face, construct, and predictive validity for symptoms related to schizophrenia. The MIA model is a powerful tool for investigating molecular mechanisms underlying the etiopathogenesis of schizophrenia-related features and for uncovering key molecular targets for intervention. Here we introduce the epidemiological bases for the MIA model and present important findings on both prenatal and postnatal variations of the polyinosine-polycytidylic approach. We further describe applications of the MIA model to studies of gene–environment and environment–environment interactions in schizophrenia. Finally, we discuss the MIA risk factor in the context of increasing evidence that immune dysregulation contributes to the manifestation of schizophrenia-related symptoms.

Original languageEnglish
Title of host publicationHandbook of Behavioral Neuroscience
PublisherElsevier B.V.
Pages175-191
Number of pages17
DOIs
Publication statusPublished - 2016 Jan 1

Publication series

NameHandbook of Behavioral Neuroscience
Volume23
ISSN (Print)1569-7339

Fingerprint

Schizophrenia
Mothers
Double-Stranded RNA
Virus Diseases
Rodentia

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Malkova, N., Wu, W-L., & Hsiao, E. Y. (2016). Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. In Handbook of Behavioral Neuroscience (pp. 175-191). (Handbook of Behavioral Neuroscience; Vol. 23). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-800981-9.00011-0
Malkova, Natalia ; Wu, Wei-Li ; Hsiao, Elaine Y. / Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. Handbook of Behavioral Neuroscience. Elsevier B.V., 2016. pp. 175-191 (Handbook of Behavioral Neuroscience).
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Malkova, N, Wu, W-L & Hsiao, EY 2016, Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. in Handbook of Behavioral Neuroscience. Handbook of Behavioral Neuroscience, vol. 23, Elsevier B.V., pp. 175-191. https://doi.org/10.1016/B978-0-12-800981-9.00011-0

Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. / Malkova, Natalia; Wu, Wei-Li; Hsiao, Elaine Y.

Handbook of Behavioral Neuroscience. Elsevier B.V., 2016. p. 175-191 (Handbook of Behavioral Neuroscience; Vol. 23).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Malkova N, Wu W-L, Hsiao EY. Modeling the Maternal Immune Activation Risk Factor for Schizophrenia. In Handbook of Behavioral Neuroscience. Elsevier B.V. 2016. p. 175-191. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-800981-9.00011-0