Abstract
The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 665-670 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1994 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience
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Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines. / Shoei-Yn Lin-Shiau, Lin-Shiau; Hsu, Kuei-Sen.
In: Pharmacology, Biochemistry and Behavior, Vol. 48, No. 3, 01.01.1994, p. 665-670.Research output: Contribution to journal › Article
TY - JOUR
T1 - Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines
AU - Shoei-Yn Lin-Shiau, Lin-Shiau
AU - Hsu, Kuei-Sen
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.
AB - The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.
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U2 - 10.1016/0091-3057(94)90329-8
DO - 10.1016/0091-3057(94)90329-8
M3 - Article
VL - 48
SP - 665
EP - 670
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -