Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines

Lin-Shiau Shoei-Yn Lin-Shiau, Kuei-Sen Hsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume48
Issue number3
DOIs
Publication statusPublished - 1994 Jan 1

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Flunitrazepam
Serotonin Receptor Agonists
Tremor
Diazepam
Benzodiazepines
Serotonin
Methoxydimethyltryptamines
Metergoline
Fenclonine
Mianserin
Cyproheptadine
Methysergide
8-Hydroxy-2-(di-n-propylamino)tetralin
5-Hydroxytryptophan
Pentobarbital
Neurons
Serotonergic Neurons
Myoclonus
Hindlimb
hydroxide ion

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

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title = "Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines",
abstract = "The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the {"}5-hydroxytryptamine (5-HT) syndrome,{"} in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.",
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Modification of 2,2′,2″-tripyridine-induced tremor in mice by serotonergic agonists and antagonists and benzodiazepines. / Shoei-Yn Lin-Shiau, Lin-Shiau; Hsu, Kuei-Sen.

In: Pharmacology, Biochemistry and Behavior, Vol. 48, No. 3, 01.01.1994, p. 665-670.

Research output: Contribution to journalArticle

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AU - Shoei-Yn Lin-Shiau, Lin-Shiau

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AB - The administration of 2,2′,2″-tripyridine produced generalized tremor, myoclonus, and hindlimb abduction, similar to the "5-hydroxytryptamine (5-HT) syndrome," in mice. Pretreatment with mianserin, cyproheptadine, methysergide, or metergoline ameliorated, whereas 5-hydroxytryptophan (5-HTP), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), or 8-hydroxy-2-[di-n-propylamino]tetraline hydrobromide (8-OH-DPAT) augmented the 2,2′,2″-tripyridine-induced tremor. Furthermore, diazepam and flunitrazepam exhibited a dose-dependent protection against 2,2′,2″-tripyridine-induced tremor in mice, but pentobarbital only had a slightly protective effect. The inhibitory effects of diazepam and flunitrazepam on the 2,2′,2″-tripyridine-induced tremor were potentiated in mice pretreated with p-chlorophenylalanine (PCPA). These observations suggest a serotonin-mediated action of 2,2′,2″-tripyridine in its tremor action and that the benzodiazepine agonist attenuation of the 2,2′,2″-tripyridine-induced tremor is probably mediated through the GABAergic inhibition of serotonergic neurons.

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