Molecular Chirality Detection with Periodic Arrays of Three-Dimensional Twisted Metamaterials

Chia Yi Lin, Chi Ching Liu, Yu Yu Chen, Kuan Yu Chiu, Jyun De Wu, Bo Lin Lin, Chang Han Wang, Yang Fang Chen, Shih Hui Chang, Yun Chorng Chang

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Rapid detection of the handiness of chiral molecules is an important topic for pharmaceutical industries because chiral drugs with opposing handiness sometimes exhibit unwanted side effects. In this research, a rapid optical method is proposed to determine the handiness of the chiral drug "Thalidomide". The platform is a large array of three-dimensional (3D) twisted metamaterials fabricated with a novel method by combining nanospherical-lens lithography (NLL) and hole-mask lithography (HML). The fabrication is high-throughput and the twisted metamaterials cover a large area. Strong circular dichroism (CD) response is observed in the near-infrared (NIR) region, which enables the chiral detection to be performed by a low-cost and portable spectroscope system. The proposed nanofabrication method significantly improves the capabilities of NLL and HML, which can be quickly adapted to fabricate various periodic 3D metamaterials. In addition, the results of this research pave the road for the rapid penetration of nanophotonics into the pharmaceutical industries.

Original languageEnglish
Pages (from-to)1152-1157
Number of pages6
JournalACS Applied Materials and Interfaces
Issue number1
Publication statusPublished - 2021 Jan 13

All Science Journal Classification (ASJC) codes

  • General Materials Science


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