Molecular mimicry between SARS coronavirus spike protein and human protein

Kuo Yuan Hwa, Wan Man Lin, Yung I. Hou, Trai Ming Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.

Original languageEnglish
Title of host publicationProceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
Pages294-298
Number of pages5
DOIs
Publication statusPublished - 2007
EventFrontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 - Jeju Island, Korea, Republic of
Duration: 2007 Oct 112007 Oct 13

Publication series

NameProceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

Other

OtherFrontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
Country/TerritoryKorea, Republic of
CityJeju Island
Period07-10-1107-10-13

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Information Systems

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