Molecular mimicry between SARS coronavirus spike protein and human protein

Kuo Yuan Hwa; Wan Man Lin; Yung I. Hou; Trai Ming Yeh

doi:10.1109/FBIT.2007.108

Molecular mimicry between SARS coronavirus spike protein and human protein

Kuo Yuan Hwa, Wan Man Lin, Yung I. Hou, Trai Ming Yeh

Department of Medical Laboratory Science and Biotechnology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.

Original language	English
Title of host publication	Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
Pages	294-298
Number of pages	5
DOIs	https://doi.org/10.1109/FBIT.2007.108
Publication status	Published - 2007
Event	Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 - Jeju Island, Korea, Republic of Duration: 2007 Oct 11 → 2007 Oct 13

Publication series

Name	Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

Other

Other	Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007
Country/Territory	Korea, Republic of
City	Jeju Island
Period	07-10-11 → 07-10-13

All Science Journal Classification (ASJC) codes

Computer Science Applications
Information Systems

Access to Document

10.1109/FBIT.2007.108

Cite this

Hwa, K. Y., Lin, W. M., Hou, Y. I., & Yeh, T. M. (2007). Molecular mimicry between SARS coronavirus spike protein and human protein. In Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 (pp. 294-298). Article 4524122 (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007). https://doi.org/10.1109/FBIT.2007.108

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title = "Molecular mimicry between SARS coronavirus spike protein and human protein",

abstract = "Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.",

author = "Hwa, {Kuo Yuan} and Lin, {Wan Man} and Hou, {Yung I.} and Yeh, {Trai Ming}",

year = "2007",

doi = "10.1109/FBIT.2007.108",

language = "English",

isbn = "0769529992",

series = "Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007",

pages = "294--298",

booktitle = "Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007",

note = "Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007 ; Conference date: 11-10-2007 Through 13-10-2007",

}

Hwa, KY, Lin, WM, Hou, YI & Yeh, TM 2007, Molecular mimicry between SARS coronavirus spike protein and human protein. in Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007., 4524122, Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007, pp. 294-298, Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007, Jeju Island, Korea, Republic of, 07-10-11. https://doi.org/10.1109/FBIT.2007.108

Molecular mimicry between SARS coronavirus spike protein and human protein. / Hwa, Kuo Yuan; Lin, Wan Man; Hou, Yung I. et al.
Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007. p. 294-298 4524122 (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Molecular mimicry between SARS coronavirus spike protein and human protein

AU - Hwa, Kuo Yuan

AU - Lin, Wan Man

AU - Hou, Yung I.

AU - Yeh, Trai Ming

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N2 - Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.

AB - Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silica results.

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SN - 9780769529998

T3 - Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007

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Hwa KY, Lin WM, Hou YI, Yeh TM. Molecular mimicry between SARS coronavirus spike protein and human protein. In Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007. 2007. p. 294-298. 4524122. (Proceedings of the Frontiers in the Convergence of Bioscience and Information Technologies, FBIT 2007). doi: 10.1109/FBIT.2007.108

Molecular mimicry between SARS coronavirus spike protein and human protein

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