Monascus purpureus-fermented products and oral cancer: A review

Wei-Hsuan Hsu, Tzu Ming Pan

Research output: Contribution to journalShort survey

19 Citations (Scopus)

Abstract

Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.

Original languageEnglish
Pages (from-to)1831-1842
Number of pages12
JournalApplied Microbiology and Biotechnology
Volume93
Issue number5
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

Monascus
Mouth Neoplasms
Citrinin
Lovastatin
Neoplasms
Paintings
Far East
Chinese Traditional Medicine
Tobacco Use
Alcohol Drinking
Mouth
Carcinogenesis
Fungi
Anti-Inflammatory Agents
Quality of Life
Survival
Growth
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

@article{3f359fea1c4a40a4aa9a15a677889207,
title = "Monascus purpureus-fermented products and oral cancer: A review",
abstract = "Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.",
author = "Wei-Hsuan Hsu and Pan, {Tzu Ming}",
year = "2012",
month = "3",
day = "1",
doi = "10.1007/s00253-012-3891-9",
language = "English",
volume = "93",
pages = "1831--1842",
journal = "Applied Microbiology and Biotechnology",
issn = "0175-7598",
publisher = "Springer Verlag",
number = "5",

}

Monascus purpureus-fermented products and oral cancer : A review. / Hsu, Wei-Hsuan; Pan, Tzu Ming.

In: Applied Microbiology and Biotechnology, Vol. 93, No. 5, 01.03.2012, p. 1831-1842.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Monascus purpureus-fermented products and oral cancer

T2 - A review

AU - Hsu, Wei-Hsuan

AU - Pan, Tzu Ming

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.

AB - Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.

UR - http://www.scopus.com/inward/record.url?scp=84857918181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857918181&partnerID=8YFLogxK

U2 - 10.1007/s00253-012-3891-9

DO - 10.1007/s00253-012-3891-9

M3 - Short survey

C2 - 22290648

AN - SCOPUS:84857918181

VL - 93

SP - 1831

EP - 1842

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

SN - 0175-7598

IS - 5

ER -