Monascus purpureus-fermented products and oral cancer: A review

Wei Hsuan Hsu, Tzu Ming Pan

Research output: Contribution to journalShort surveypeer-review

27 Citations (Scopus)


Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life.

Original languageEnglish
Pages (from-to)1831-1842
Number of pages12
JournalApplied Microbiology and Biotechnology
Issue number5
Publication statusPublished - 2012 Mar

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology


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