Monitoring hemodynamic changes in brain infarct area of rats using diffuse optical imaging

Kang Yu Chu, Chun Wei Wu, Jia-Jin Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Stroke is a heterogeneous syndrome caused by various diseases resulting from disruption of cerebral blood flow (CBF) and brain tissue necrosis. Ischemic stroke is the major type of this syndrome induced by brain infarction. The infarct area will accompany with cerebral edema which could change the optical properties of the brain tissue. Near infrared spectroscopy (NIRS) was commonly used in measuring the concentration of the main chromophores in the blood oxyand deoxy- hemoglobin for acquiring the hemodynamic or metabolic change in the tissue. In our previous studies, we have shown the hemodynamic activity of stroke rat using frequency domain NIRS (FDNIRS). To precisely locate the ischemic infarct region within whole brain, we develop a noninvasive, diffuse optical imaging (DOI) system based on NIRS. To localize the infarct area and morphological information, the 2D scanning system with DOI technique was developed. The optical properties of the tissue i.e. absorption and scattering coefficient, representing the photon transmission model in the tissue, were applied to observe the structural changes of the brain tissue. In the pilot study, we have applied FDNIRS to monitor the changes of blood oxygen level controlled by neurovascular coupling in ischemic brain. By comparing the FDNIRS measurement result of the sham group with the middle carotid arterial occlusion (MCAO) group stroke rat on post operation day 3. We found that there is a high correlation between the reduced scattering coefficient and the infarct area tissue. The system has been applied to observe the in-vivo experiment of ischemic animal stroke model. Further study can develop optical techniques for monitoring and diagnosing the progress of stroke and the novel therapy methods.

Original languageEnglish
Title of host publication7th WACBE World Congress on Bioengineering, 2015
EditorsChwee Teck Lim, James Goh
PublisherSpringer Verlag
Pages68-71
Number of pages4
ISBN (Print)9783319194516
DOIs
Publication statusPublished - 2015 Jan 1
Event7th World Congress on Bioengineering, WACBE 2015 - Kent Ridge, Singapore
Duration: 2015 Jul 62015 Jul 8

Publication series

NameIFMBE Proceedings
Volume52
ISSN (Print)1680-0737

Other

Other7th World Congress on Bioengineering, WACBE 2015
CountrySingapore
CityKent Ridge
Period15-07-0615-07-08

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Chu, K. Y., Wu, C. W., & Chen, J-J. (2015). Monitoring hemodynamic changes in brain infarct area of rats using diffuse optical imaging. In C. T. Lim, & J. Goh (Eds.), 7th WACBE World Congress on Bioengineering, 2015 (pp. 68-71). (IFMBE Proceedings; Vol. 52). Springer Verlag. https://doi.org/10.1007/978-3-319-19452-3_19