TY - JOUR
T1 - Monitoring of xenobiotic ligands for human estrogen receptor and aryl hydrocarbon receptor in industrial wastewater effluents
AU - Chou, Pei Hsin
AU - Liu, Tong Cun
AU - Lin, Yi Ling
N1 - Funding Information:
This work was supported by the National Science Council, Taiwan (NSC 98-2218-E-006-006, NSC 98-2221-E-006-020-MY3 , and NSC 100-2221-E-006-037-MY2 ). The authors thank Dr. Miller from Tulane University, USA, and Dr. Matsuda from Kyoto University, Japan, for providing the recombinant strains.
PY - 2014/7/30
Y1 - 2014/7/30
N2 - Industrial wastewater contains a variety of toxic substances, which may severely contaminate the aquatic environment if discharged without adequate treatment. In this study, effluents from a thin film transistor liquid crystal display wastewater treatment plant and the receiving water were analyzed by bioassays and liquid chromatography-tandem mass spectrometry to investigate the presence of estrogenic compounds, aryl hydrocarbon receptor (AhR) agonists, and genotoxicants. Xenobiotic AhR agonists were frequently detected and, in particular, strong AhR agonist activity and genotoxicity were found in the suspended solids of the aeration tank outflow. The high AhR agonist activity in the final effluent (FE) and the downstream river water suggested that the treatment plant failed to remove the wastewater-related AhR agonists. In contrast, although significant estrogenic potency could be detected in raw wastewater or effluents from different treatment processes, the FE and the receiving river water exhibited no or weak estrogenicity. Instrumental analysis showed that bisphenol A was often detected in water samples. However, the investigated estrogenic compounds could only account for a small portion of the estrogenicity in the collected samples. Therefore, further investigation is necessary to identify the major estrogenic compounds and AhR agonist contaminants in the wastewater effluents.
AB - Industrial wastewater contains a variety of toxic substances, which may severely contaminate the aquatic environment if discharged without adequate treatment. In this study, effluents from a thin film transistor liquid crystal display wastewater treatment plant and the receiving water were analyzed by bioassays and liquid chromatography-tandem mass spectrometry to investigate the presence of estrogenic compounds, aryl hydrocarbon receptor (AhR) agonists, and genotoxicants. Xenobiotic AhR agonists were frequently detected and, in particular, strong AhR agonist activity and genotoxicity were found in the suspended solids of the aeration tank outflow. The high AhR agonist activity in the final effluent (FE) and the downstream river water suggested that the treatment plant failed to remove the wastewater-related AhR agonists. In contrast, although significant estrogenic potency could be detected in raw wastewater or effluents from different treatment processes, the FE and the receiving river water exhibited no or weak estrogenicity. Instrumental analysis showed that bisphenol A was often detected in water samples. However, the investigated estrogenic compounds could only account for a small portion of the estrogenicity in the collected samples. Therefore, further investigation is necessary to identify the major estrogenic compounds and AhR agonist contaminants in the wastewater effluents.
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U2 - 10.1016/j.jhazmat.2014.02.049
DO - 10.1016/j.jhazmat.2014.02.049
M3 - Article
C2 - 24680543
AN - SCOPUS:84903770160
SN - 0304-3894
VL - 277
SP - 13
EP - 19
JO - Journal of Hazardous Materials
JF - Journal of Hazardous Materials
ER -