Monitoring perspiration from palms of hypohidrosis patients with a stopped-flow conductometric mini-system

Background: Sensitive and real-time methods are required to characterize the symptoms and resolve the complicated pathology of hypohidrosis. Method: We constructed a conductometric humidity sensor and a stopped-flow manifold with suitable dynamic range for monitoring impaired perspiration. The mini-sensor was coated with a water-absorbing polymer of poly-(2-acrylamido-2-methylpropane sulfonate). Results: Perspiration from palms of normal individuals and hypohidrosis patients were monitored and compared. Tangent slopes of the sensorograms were capable of discriminating hypohidrosis patients from normal individuals. Conclusion: The conductometric min-sensor and the stopped-flow manifold were proven to be useful as a diagnostic tool for hypohidrosis.