Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease

Kung-Chao Chang, Yu Chu Wang, Liang-Yi Hung, Wan Ting Huang, Jen Hui Tsou, Dan M Jones, Hsiang Lin Song, Yu-Min Yeh, Lin Yuan Kao, L. Jeffrey Medeiros

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Abstract

Hyaline vascular Castleman disease is traditionally regarded as a reactive hyperplastic process. Occasional cases, however, have been reported with cytogenetic anomalies bringing this concept into question. In this study, we used conventional and methylation-specific polymerase chain reaction methods to assess the human androgen receptor α (HUMARA) gene in 29 female patients with hyaline vascular Castleman disease and compared the results with three cases of plasma cell Castleman disease and 20 cases of age-matched lymphoid hyperplasia. We also assessed for immunoglobulin gene and T-cell receptor gene rearrangements, and conventional cytogenetic analysis was performed in three cases of hyaline vascular Castleman disease. In cases with informative results, conventional and methylation-specific human androgen receptor α gene analyses yielded a monoclonal pattern in 10 of 19 (53%) and 17 of 23 (74%) cases of hyaline vascular Castleman disease, respectively. A monoclonal pattern was also detected in three cases of plasma cell Castleman disease but not in cases of lymphoid hyperplasia. The frequency of monoclonality was higher for lesions >5 cm in size (100%) and for the stromal-rich variant (91%). Cytogenetic abnormalities in stromal cells were revealed in two cases of hyaline vascular Castleman disease and no cases showed monoclonal immunoglobulin or T-cell receptor gene rearrangements. Follow-up data showed persistent disease in 4 of 23 (17%) patients. We conclude that hyaline vascular Castleman disease is often a monoclonal proliferation, most likely of lymph node stromal cells.

Original languageEnglish
Pages (from-to)823-831
Number of pages9
JournalModern Pathology
Volume27
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Giant Lymph Node Hyperplasia
Hyalin
Vascular Diseases
Chromosome Aberrations
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Stromal Cells
Plasma Cells
Methylation
Hyperplasia
Immunoglobulin Genes
Cytogenetic Analysis
Cytogenetics
Genes
Immunoglobulins
Lymph Nodes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Chang, Kung-Chao ; Wang, Yu Chu ; Hung, Liang-Yi ; Huang, Wan Ting ; Tsou, Jen Hui ; M Jones, Dan ; Song, Hsiang Lin ; Yeh, Yu-Min ; Kao, Lin Yuan ; Medeiros, L. Jeffrey. / Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease. In: Modern Pathology. 2014 ; Vol. 27, No. 6. pp. 823-831.
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Chang, K-C, Wang, YC, Hung, L-Y, Huang, WT, Tsou, JH, M Jones, D, Song, HL, Yeh, Y-M, Kao, LY & Medeiros, LJ 2014, 'Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease', Modern Pathology, vol. 27, no. 6, pp. 823-831. https://doi.org/10.1038/modpathol.2013.202

Monoclonality and cytogenetic abnormalities in hyaline vascular Castleman disease. / Chang, Kung-Chao; Wang, Yu Chu; Hung, Liang-Yi; Huang, Wan Ting; Tsou, Jen Hui; M Jones, Dan; Song, Hsiang Lin; Yeh, Yu-Min; Kao, Lin Yuan; Medeiros, L. Jeffrey.

In: Modern Pathology, Vol. 27, No. 6, 01.01.2014, p. 823-831.

Research output: Contribution to journalArticle

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