Monolayers (Langmuir films) behavior of multi-component systems composed of a bile acid with different sterols and with their 1:1 mixtures

Shigemi Nagadome, Nozomi S. Suzuki, Yauko Mine, Takeo Yamaguchi, Hiromichi Nakahara, Osamu Shibata, Chien-Hsiang Chang, Gohsuke Sugihara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Different physicochemical properties of Langmuir films (monolayers) composed of 10 mixed systems of a bile acid, deoxycholic acid (DC) with various plant sterols, such as stigmasterol (Stig), β-sitosterol (Sito) and campesterol (Camp) and a stanol, cholestanol (Chsta) in addition to an animal sterol, cholesterol (Ch) [these sterols and Chsta are abbreviated as St] and DC with 1:1 St mixtures; (Ch + Chsta), (Ch + Stig), (Stig + Chsta), (Ch + Sito) and (Ch + Camp) on the substrate of 5 M aqueous NaCl solution (pH 1.2) at 25 °C, were investigated in terms of mean surface area per molecule (Am), the partial molecular area (PMA), surface excess Gibbs energy (ΔG(ex)), interaction parameter (Ip) as well as activity coefficients (f1 and f2) in 2-D phase of each binary (or ternary) component system and elasticity (Cs-1) of formed films; these were analyzed on the basis of the respective surface pressure (π) versus Am isotherms as a function of mole fraction of Sts (Xst) in the DC/St(s) mixtures at discrete surface pressures. Notable findings are: (i) all the binary component systems did form patched film type monolayers consisting of (a) DC-dominant film solubilizing a trace amount of St molecules and (b) St dominant film dissolving a small amount of DC molecules, (ii) DC in 2-D phase exhibited a transition from LE film to LC film at a constant pressure (πC1) accompanied by compression and (iii) ΔG(ex) as well as Ip was found to be greatly dependent on (a) the combinations of DC with different St species and (b) to be markedly varied by a difference in mixing ratio of DC to Sts. Compressibility (or elasticity) analyses and fluorescence microscopy images could support the above findings as well as interpretation.

Original languageEnglish
Pages (from-to)121-136
Number of pages16
JournalColloids and Surfaces B: Biointerfaces
Volume58
Issue number2
DOIs
Publication statusPublished - 2007 Aug 1

Fingerprint

Deoxycholic Acid
monomolecular films
Langmuir Blodgett films
Sterols
Bile Acids and Salts
Monolayers
Cholestanol
Cholesterol
cholesterol
acids
Acids
Stigmasterol
Molecules
Elasticity
Pressure
molecules
elastic properties
Phytosterols
Fluorescence microscopy
Activity coefficients

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Nagadome, Shigemi ; Suzuki, Nozomi S. ; Mine, Yauko ; Yamaguchi, Takeo ; Nakahara, Hiromichi ; Shibata, Osamu ; Chang, Chien-Hsiang ; Sugihara, Gohsuke. / Monolayers (Langmuir films) behavior of multi-component systems composed of a bile acid with different sterols and with their 1:1 mixtures. In: Colloids and Surfaces B: Biointerfaces. 2007 ; Vol. 58, No. 2. pp. 121-136.
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Monolayers (Langmuir films) behavior of multi-component systems composed of a bile acid with different sterols and with their 1:1 mixtures. / Nagadome, Shigemi; Suzuki, Nozomi S.; Mine, Yauko; Yamaguchi, Takeo; Nakahara, Hiromichi; Shibata, Osamu; Chang, Chien-Hsiang; Sugihara, Gohsuke.

In: Colloids and Surfaces B: Biointerfaces, Vol. 58, No. 2, 01.08.2007, p. 121-136.

Research output: Contribution to journalArticle

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T1 - Monolayers (Langmuir films) behavior of multi-component systems composed of a bile acid with different sterols and with their 1:1 mixtures

AU - Nagadome, Shigemi

AU - Suzuki, Nozomi S.

AU - Mine, Yauko

AU - Yamaguchi, Takeo

AU - Nakahara, Hiromichi

AU - Shibata, Osamu

AU - Chang, Chien-Hsiang

AU - Sugihara, Gohsuke

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