Mouse left ventricular volume estimation by use of the conductance catheter measurement system

Chia-Ling Wei, Ming Hsien Shih

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For cardiac gene researches, a method to quantify the cardiac functions is needed. Ventricular pressure-volume loop analysis is a standard tool to evaluate and quantify the myocardial and cardiac functions. The ventricular volume of transgenic mice is typically estimated by using the conductance catheter measurement system, which measures instantaneous ventricular conductance and then converts it into volume. The classic conductance-to-volume conversion equation was proposed by Baan et al. in 1984, but its accuracy is limited. The volume estimation accuracy of Baan's equation versus different possible mouse left ventricular volume ranges is investigated in this work. The results shows that the error of volume estimation is closely related to end-diastolic volume: the error increases with increasing end-diastolic volume. Therefore, it may not be appropriate to use Baan's equation on the mice with the disease of congestive heart failure, which results in larger end-diastolic volumes.

Original languageEnglish
Title of host publication2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09
DOIs
Publication statusPublished - 2009 Sep 17
Event2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09 - Chengdu, China
Duration: 2009 Apr 282009 Apr 29

Publication series

Name2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09

Other

Other2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09
CountryChina
CityChengdu
Period09-04-2809-04-29

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Modelling and Simulation

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  • Cite this

    Wei, C-L., & Shih, M. H. (2009). Mouse left ventricular volume estimation by use of the conductance catheter measurement system. In 2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09 [4960841] (2009 IEEE Circuits and Systems International Conference on Testing and Diagnosis, ICTD'09). https://doi.org/10.1109/CAS-ICTD.2009.4960841