Multicenter study of azole-resistant aspergillus fumigatus clinical isolates, Taiwan

Chi Jung Wu, Wei Lun Liu, Chih Cheng Lai, Chien Ming Chao, Wen Chien Ko, Hsuan Chen Wang, Ching Tzu Dai, Ming I. Hsieh, Pui Ching Choi, Jia Ling Yang, Yee Chun Chen

Research output: Contribution to journalArticle

Abstract

In a multicenter study, we determined a prevalence rate of 4% for azole-resistant Aspergillus fumigatus in Taiwan. Resistance emerged mainly from the environment (TR34/ L98H, TR34/L98H/S297T/F495I, and TR46/Y121F/T289A mutations) but occasionally during azole treatment. A high mortality rate observed for azole-resistant aspergillosis necessitates diagnostic stewardship in healthcare and antifungal stewardship in the environment.

Original languageEnglish
Pages (from-to)806-809
Number of pages4
JournalEmerging infectious diseases
Volume26
Issue number4
DOIs
Publication statusPublished - 2020 Apr

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Wu, C. J., Liu, W. L., Lai, C. C., Chao, C. M., Ko, W. C., Wang, H. C., Dai, C. T., Hsieh, M. I., Choi, P. C., Yang, J. L., & Chen, Y. C. (2020). Multicenter study of azole-resistant aspergillus fumigatus clinical isolates, Taiwan. Emerging infectious diseases, 26(4), 806-809. https://doi.org/10.3201/eid2604.190840