Multicenter surveillance of antimicrobial resistance of major bacterial pathogens in intensive care units in 2000 in Taiwan

Po Ren Hsueh, Yung Ching Liu, Dine Yang, Jing Jou Yan, Tsu Lan Wu, Wen Kuei Huang, Jiunn Jong Wu, Wen-Chien Ko, Hsieh Shong Leu, Chong Ren Yu, Kwen Tay Luh

Research output: Contribution to journalArticle

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Abstract

A susceptibility surveillance study of 1, 274 bacterial isolates recovered from various clinical specimens from patients in intensive care units (ICUs) of five major teaching hospitals was carried out from March, 2000, to June, 2000, in Taiwan. This study demonstrated a high rate (66%) of oxacillin resistance in Staphylococcus aureus (ORSA), a high rate of nonsusceptibility to penicillin (intermediate, 50% and highly resistant, 8%), and high rates of cefotaxime nonsusceptibility for S. pneumoniae (intermediate, 29% and resistant, 4%), Enterobacter cloacae (57%), Serratia marcescens (34%), and Citrobacter freundii (60 %). High rate of ceftazidime nonsusceptibility for Pseudomonas aeruginosa (22%), and high rates of imipenem nonsusceptibility for P. aeruginosa (15%) and Acinetobacter baumannii (22%) were also found. The percentage (11.9%) of extendedspectrum β-lactamase (ESBL)-producing Escherichia coli was greater than that (11.3%) for Klebsiella pneumoniae. Rates of quinupristin-dalfopristin nonsusceptibility for S. pneumoniae (42%), Enterococcus faecium (71%), and ORSA (39%) were high, but no vancomycin-resistant enterococci were found in this study. The resistance rates of some pathogen varied by institution or type of ICUs. Surveillance for antimicrobial resistance among bacterial pathogens in hospitals, particularly in ICU settings with a preexisting higher resistance burden, is mandatory in establishing and/or modifying guidelines for empirical treatment of severe infections in ICU patients caused by these antimicrobial-resistant pathogens.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalMicrobial Drug Resistance
Volume7
Issue number4
DOIs
Publication statusPublished - 2001 Dec 1

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Taiwan
Intensive Care Units
Oxacillin
Pseudomonas aeruginosa
Staphylococcus aureus
Pneumonia
Citrobacter freundii
Enterobacter cloacae
Acinetobacter baumannii
Enterococcus faecium
Serratia marcescens
Ceftazidime
Cefotaxime
Imipenem
Klebsiella pneumoniae
Teaching Hospitals
Penicillins
Guidelines
Escherichia coli
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

Cite this

Hsueh, Po Ren ; Liu, Yung Ching ; Yang, Dine ; Yan, Jing Jou ; Wu, Tsu Lan ; Huang, Wen Kuei ; Wu, Jiunn Jong ; Ko, Wen-Chien ; Leu, Hsieh Shong ; Yu, Chong Ren ; Luh, Kwen Tay. / Multicenter surveillance of antimicrobial resistance of major bacterial pathogens in intensive care units in 2000 in Taiwan. In: Microbial Drug Resistance. 2001 ; Vol. 7, No. 4. pp. 373-382.
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abstract = "A susceptibility surveillance study of 1, 274 bacterial isolates recovered from various clinical specimens from patients in intensive care units (ICUs) of five major teaching hospitals was carried out from March, 2000, to June, 2000, in Taiwan. This study demonstrated a high rate (66{\%}) of oxacillin resistance in Staphylococcus aureus (ORSA), a high rate of nonsusceptibility to penicillin (intermediate, 50{\%} and highly resistant, 8{\%}), and high rates of cefotaxime nonsusceptibility for S. pneumoniae (intermediate, 29{\%} and resistant, 4{\%}), Enterobacter cloacae (57{\%}), Serratia marcescens (34{\%}), and Citrobacter freundii (60 {\%}). High rate of ceftazidime nonsusceptibility for Pseudomonas aeruginosa (22{\%}), and high rates of imipenem nonsusceptibility for P. aeruginosa (15{\%}) and Acinetobacter baumannii (22{\%}) were also found. The percentage (11.9{\%}) of extendedspectrum β-lactamase (ESBL)-producing Escherichia coli was greater than that (11.3{\%}) for Klebsiella pneumoniae. Rates of quinupristin-dalfopristin nonsusceptibility for S. pneumoniae (42{\%}), Enterococcus faecium (71{\%}), and ORSA (39{\%}) were high, but no vancomycin-resistant enterococci were found in this study. The resistance rates of some pathogen varied by institution or type of ICUs. Surveillance for antimicrobial resistance among bacterial pathogens in hospitals, particularly in ICU settings with a preexisting higher resistance burden, is mandatory in establishing and/or modifying guidelines for empirical treatment of severe infections in ICU patients caused by these antimicrobial-resistant pathogens.",
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Multicenter surveillance of antimicrobial resistance of major bacterial pathogens in intensive care units in 2000 in Taiwan. / Hsueh, Po Ren; Liu, Yung Ching; Yang, Dine; Yan, Jing Jou; Wu, Tsu Lan; Huang, Wen Kuei; Wu, Jiunn Jong; Ko, Wen-Chien; Leu, Hsieh Shong; Yu, Chong Ren; Luh, Kwen Tay.

In: Microbial Drug Resistance, Vol. 7, No. 4, 01.12.2001, p. 373-382.

Research output: Contribution to journalArticle

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AU - Luh, Kwen Tay

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N2 - A susceptibility surveillance study of 1, 274 bacterial isolates recovered from various clinical specimens from patients in intensive care units (ICUs) of five major teaching hospitals was carried out from March, 2000, to June, 2000, in Taiwan. This study demonstrated a high rate (66%) of oxacillin resistance in Staphylococcus aureus (ORSA), a high rate of nonsusceptibility to penicillin (intermediate, 50% and highly resistant, 8%), and high rates of cefotaxime nonsusceptibility for S. pneumoniae (intermediate, 29% and resistant, 4%), Enterobacter cloacae (57%), Serratia marcescens (34%), and Citrobacter freundii (60 %). High rate of ceftazidime nonsusceptibility for Pseudomonas aeruginosa (22%), and high rates of imipenem nonsusceptibility for P. aeruginosa (15%) and Acinetobacter baumannii (22%) were also found. The percentage (11.9%) of extendedspectrum β-lactamase (ESBL)-producing Escherichia coli was greater than that (11.3%) for Klebsiella pneumoniae. Rates of quinupristin-dalfopristin nonsusceptibility for S. pneumoniae (42%), Enterococcus faecium (71%), and ORSA (39%) were high, but no vancomycin-resistant enterococci were found in this study. The resistance rates of some pathogen varied by institution or type of ICUs. Surveillance for antimicrobial resistance among bacterial pathogens in hospitals, particularly in ICU settings with a preexisting higher resistance burden, is mandatory in establishing and/or modifying guidelines for empirical treatment of severe infections in ICU patients caused by these antimicrobial-resistant pathogens.

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