Multicentre, placebo-controlled trial of lorcaserin for weight management in Chinese population

Chia Wen Lu, Chih Jen Chang, Yi Ching Yang, Wen Yuan Lin, Kuo Chin Huang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective: This study aimed to evaluate the effects of lorcaserin on body weight, cardiovascular risk factors, and safety in obese patients in Taiwan. Methods: In this double-blind, randomised controlled trial, 171 obese adults were assigned to receive lorcaserin at a dose of 10 mg, or placebo, twice a day for 24 weeks. Diet and exercise counselling were given to all patients through the treatment period. Primary outcomes were proportion of patients achieving at least 5% and 10% reduction in body weight and mean change in body weight. Safety and tolerability endpoints such as Beck Depression Inventory-II, blood biochemistry, vital signs, and electrocardiogram were monitored. Results: More patients receiving lorcaserin lost at least 5% body weight than receiving placebo (52.4% and 28.1%, P = 0.001) with an average weight reduction of 5.8 kg (95% CI: −6.91, −4.70) in lorcaserin group and those of 3.6 kg (95% CI: −4.95, −2.33) in placebo group (P < 0.05). The most common adverse effect with greater incidence in the lorcaserin group was self-limited dizziness. Serious adverse effect were rare and was reported by slightly more patients taking placebo than lorcaserin. Conclusions: In this multicentre, double-blinded placebo-controlled trial, lorcaserin was effective and well-tolerable in Asia group.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalObesity Research and Clinical Practice
Issue number5
Publication statusPublished - 2018 Sep 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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